I'm 43, have w/mostly seronegative (high CRP only) RA (diag. 1.5 yrs ago, pain 5.5 yrs). Used plaquenil, MTX injections, and Enbrel before Humira. Was on Celebrex, switching now to Mobic, but might switch back (have to take daily Prilosec with Celebrex as I had heartburn for 1st time in my life). Nothing worked to feel better, but the blood work is slowly showing improvement. (Except on MTX, which RAISED my CRP and made me feel out of breath.) I've done 5 Humira shots so far (biweekly). Humira pen is a nightmare compared to Enbrel pen. With Enbrel, you had two clicks: one to let you know you've started (the button worked when you pressed it), and one to tell you (oh, joy!) it was over. Humira doesn't have the 2nd click, so since I inject in my thigh, how am I supposed to see the window turn yellow? Of course on the DVD, they show injection into the stomach, which is not an option for me. I hate having to depend on my husband to be a part of this, but he has to sit by me and watch the stupid window. (His life has already been turned upside down by my RA!) I also think the Humira pen is more painful than Enbrel while injecting. And it's weird that it REALLY hurts when I put the gauze on with Humira, never w/Enbrel. I hate that with Enbrel, I flattened out my skin to inject; with Humira, I have to plump it up (not easy with all of our hands!). Nevertheless, I would happy to do ANY injection since all I've done (incl. MTX) are not anywhere as painful as my knees are 95% of every day. All of the drugs have been completely ineffective for me, and thankfully, besides the out-of-breath MTX, no side effects besides bruising (both) and mild swelling (Humira). Celebrex improved my life so that, even though I can't leave the house to walk anywhere, I could stand and cook, etc. I was told by my rheumie that I will go to Orencia next - going to try 1-2 more months (total of 3-4). He said I'd skip Remicade since it & Humira are closely related.Read More Read Less