Licorice Root May Keep Mental Skills Sharp
Compound Derived From Licorice Root May Fight Effects of Aging on Brain
March 29, 2004 -- A compound derived from licorice root may
help slow the effects of aging on the brain and keep mental skills sharp.
Researchers found the compound, known as carbenoxolone, appears
to inhibit an enzyme in the brain that is involved in making stress-related
hormones, which have been associated with age-related mental decline.
The study, published in the online early edition of the
Proceedings of the National Academy of Sciences, showed daily
supplementation with the compound improved verbal fluency in healthy elderly
men and improved verbal memory in older adults with diabetes.
Although this was a small study and more research is needed to
confirm the results, researchers say the licorice root compound may offer a new
way to help prevent the normal decline in memory and other cognitive skills
people experience as they grow older.
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Licorice Root May Fight Effects of Aging on Brain
Researchers say previous human and animal studies have shown
that differences in cognitive function can be attributed to differences in
long-term exposure to hormones produced by the adrenal glands, such as
In the study, researchers examined whether inhibiting levels of
an enzyme required to increase the activity of these hormones with the licorice
root compound might have any effect on cognitive function.
A group of 10 healthy men aged 55-75 years and 12 older adults
with diabetes were randomly assigned to take either 100 mg of carbenoxolone per
day or a placebo. Neither group had dementia or other impairment, but had only
the expected age-related changes in mental function.
After four weeks, researchers found healthy men that took the
supplement performed better on a word association test that assessed their
verbal fluency skills.
After six weeks of using the compound, the verbal memory skills
among the people with diabetes improved, according to various list learning and
paragraph recall tests.
Previous studies have suggested that the licorice root compound
might increase insulin sensitivity and improve diabetes, but glucose control
levels remained unchanged during the study in this group.
Cortisol levels in the blood also remained unchanged in the
study. Researchers say those results suggest that carbenoxolone may act
directly on brain cells and reduce the amount of the hormone circulating in the
brain to prevent or slow age-related declines in cognitive function.