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Alzheimer's Disease Health Center

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Beta-Amyloid May Identify Alzheimer’s Disease

Studies Suggest Potential Approach for Identify People at Risk for Alzheimer’s
WebMD Health News
Reviewed by Laura J. Martin, MD

Jan. 18, 2011 -- Two new studies suggest the protein fragment beta-amyloid may be a useful biomarker to identify people at risk for Alzheimer’s disease.

Researchers have long searched for such biomarkers to identify those at risk for Alzheimer’s early in the course of the disease, before significant dementia occurs. That search has largely focused on beta-amyloid, which builds up in the brains of people with Alzheimer’s.

A definitive diagnosis of Alzheimer’s disease requires the presence of beta-amyloid deposits in the brain at autopsy.

The new studies suggest the protein may be a useful marker of disease long before death occurs.

Both studies appear Wednesday in TheJournal of the American Medical Association.

Highlighting Beta-Amyloid Deposits

In one study, researchers combined PET imaging with the experimental radioactive drug florbetapir, which is designed to highlight beta-amyloid deposits in the brain.

To prove its usefulness in living patients, the investigators designed a novel study involving people presumed to be in their last months of life due to either Alzheimer’s or some other illness.

An average of 99 days before their deaths, 29 patients underwent PET imaging following intravenous administration of the experimental drug.

The imaging identified 15 patients who met the pathological criteria for Alzheimer’s disease, and the diagnosis or lack of diagnosis was confirmed for all but one of the 29 patients at autopsy.

In a separate analysis involving 74 people between the ages of 18 and 50 with no evidence of cognitive decline, all of the images were negative for significant beta-amyloid deposits.

Study researcher Christopher Clark, MD, says the finding shows the value of the imaging technique for ruling out Alzheimer’s disease in patients with memory loss and other symptoms of cognitive decline.

Clark is medical director for Avid Radiopharmaceuticals, which developed florbetapir. Avid was purchased by drug maker Eli Lilly & Company late last year.

“This study shows a very high correlation between the imaging and the presence of amyloid in the brain at autopsy,” he tells WebMD.

FDA Advisory Panel

Lilly is seeking FDA approval to market florbetapir for the detection of beta-amyloid in the brain, and an FDA advisory panel is scheduled to discuss the matter on Thursday.

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