Understanding Gout -- Diagnosis & Treatment

How Is Gout Diagnosed?

To diagnose gout, blood and urine tests are needed but may not always give the answer.

Demonstrating high uric acid in the blood is essential, but you can have a high level of uric acid without having gout. Or you may have normal uric acid levels at the time of a gout attack.

To confirm the presence of gout, fluid drawn from the affected joint may be examined under a special polarizing microscope to see if it shows the characteristic crystals.

X-rays are useful in confirming long-term or chronic gout but often not useful in acute cases.

What Are the Treatments for Gout?

Anyone who experiences a gout attack quickly realizes that the first order of business is to ease the pain. Typically, an anti-inflammatory drug is used to control pain and inflammation. Ice applied to the affected joint is also helpful.

The immediate symptoms of gout will usually disappear in a few days or a week. Nonetheless, each instance of suspected gout should be diagnosed and treated by a doctor. Left untreated, uric acid deposits can eventually cause irreversible damage to the joints, kidneys, and other tissues.

For a gout attack, many doctors recommend oral doses of ibuprofen or naproxen, available in both prescription and nonprescription versions, or other anti-inflammatory drugs such as indomethacin. If you are taking aspirin, your doctor may recommend that you stop it temporarily. Aspirin can slow the elimination of uric acid and make gout worse. But if you take a low dose of aspirin to prevent other problems such as a heart attack, check with your doctor before stopping it.

Oral steroid medications or injections in the affected joint may be helpful in reducing pain and inflammation in severe attacks or chronic cases. However, steroids can have undesirable side effects and must always be given by a doctor.

Another treatment for acute gout is colchicine. It can reduce the risk of recurrent attacks and is most effective if taken within the first 12 hours of a gout attack. CAUTION: Colchicine may cause serious adverse side effects, especially if taken in high doses, or may interact with a number of antidepressants, tranquilizers, or antihistamines. And because of the risk of birth defects, pregnant women should not take it.

Continued

Once you've had an attack of gout, it's important to take steps toward preventing another attack.

Your doctor will probably advise you to cut out certain protein-rich foods, especially those high in purines, which will break down into uric acid. These foods include red meats, organ meats, anchovies, shellfish, fatty fish, asparagus, spinach, and most dried beans. You should drink plenty of liquids but avoid alcohol, especially beer, which contains high amounts of purines. Obese patients will be advised to lose weight.

After the pain of a gout attack begins to resolve, the next step is to lower the level of uric acid in the blood. The goal of lowering blood uric acid is to slowly dissolve deposits of uric acid in the joint. Lowering the body's level of uric acid can be done through the diet but usually requires drugs.

The most common drug used to prevent gout attacks is allopurinol (Zyloprim). It decreases the production of uric acid in the body. Side effects of allopurinol include rashes, drowsiness, nausea, and diarrhea, and it can have adverse reactions with other medications, particularly blood thinners and diuretics. Allopurinol should not be taken by patients with poor kidney or liver functions.

Another drug called febuxostat (Uloric) is approved for chronic management of hyperuricemia (elevated levels of uric acid) in gout patients. It helps prevent uric acid production and lowers elevated uric acid levels. The most commonly reported adverse events in Uloric's clinical trials were liver function abnormalities, nausea, rash, and joint pain.

Some people with gout have high uric acid levels in their blood because their kidneys are not able to get rid of uric acid quickly enough. Drugs like probenecid and sulfinpyrazone increase the excretion of uric acid in the urine, thus lowering the level in the blood. But like other medications used to combat gout, probenecid and sulfinpyrazone may cause adverse interactions with other drugs or complications with existing ailments such as blood disorders, ulcers, and kidney problems.

Newly approved lesinurad (Zurampic) helps the body get rid of uric acid in the urine and is recommended to be taken in conjunction with another medication like allupruinol. Common complaints include headache, reflux, blood creatinine and Influenza. It has also been found to trigger kidney failure when taken on its ow.n

Continued

The drug pegloticase (Krystexxa) can effectively treat 40% of adults with long-standing chronic gout who do not improve with or cannot tolerate other treatments. It is given intravenously and changes uric acid into another form that can be cleared from the body by the kidneys. Krystexxa does have some side effects. A quarter of the patients who participated in the clinical trials experienced a severe allergic reaction to the drug. Health care providers pretreat patients with an antihistamine, acetaminophen, and a corticosteroid to reduce the risk of an allergic reaction.

In many cases, prompt treatment with appropriate drugs solves the problem of gout permanently. People with recurring gout attacks may have to remain on drugs to prevent further attacks, sometimes for life.

WebMD Medical Reference Reviewed by Jennifer Robinson, MD on February 03, 2016

Sources

SOURCES: 

The Mayo Clinic:  "Gout."

CDC: "Arthritis: Gout."

WebMD Health News: "FDA Approves Krystexxa to Treat Gout." 

© 2016 WebMD, LLC. All rights reserved.

Pagination