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Pregnancy and Amniocentesis

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During pregnancy, the fetus is surrounded by amniotic fluid, a substance much like water. Amniotic fluid contains live fetal cells and other substances, such as alpha-fetoprotein (AFP). These substances provide important information about your baby's health before birth.

What Is Amniocentesis?

Amniocentesis is a prenatal test in which a small amount of amniotic fluid is removed from the sac surrounding the fetus for testing. The sample of amniotic fluid (less than one ounce) is removed through a fine needle inserted into the uterus through the abdomen, under ultrasound guidance. The fluid is then sent to a laboratory for analysis. Different tests can be performed on a sample of amniotic fluid, depending on the genetic risk and indication for the test.

Why Is an Amniocentesis Performed?

A complete anatomical ultrasound will be done prior to amniocentesis. but amniocentesis is performed to look for certain types of birth defects, such as Down syndrome, a chromosomal abnormality.

Because amniocentesis presents a small risk for both the mother and her baby, the prenatal test is generally offered to women who have a significant risk for genetic diseases, including those who:

  • Have an abnormal ultrasound
  • Have a family history of certain birth defects
  • Have previously had a child or pregnancy with a birth defect

Amniocentesis does not detect all birth defects, but it can be used to detect the following conditions if the parents have a significant genetic risk:

Amniocentesis can  detect certain neural tube defects (diseases where the brain and spinal column don't develop properly), such as spina bifida and anencephaly

Because ultrasound is performed at the time of amniocentesis, it may detect birth defects that are not detected by amniocentesis (such as cleft palate, cleft lip, club foot, or heart defects). There are some birth defects, however, that will not be detected by either amniocentesis or ultrasound.

If you are having an amniocentesis, you may ask to find out the baby's sex; amniocentesis is the most accurate way to determine the baby's gender before birth.

An amniocentesis can also be done during the third trimester of the pregnancy to determine if the baby's lungs are mature enough for delivery, or to evaluate the amniotic fluid for infection.


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