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Brain & Nervous System Health Center

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Stem Cells for ALS: Inside a Clinical Trial

ALS Patient Volunteers for Stem Cell Transplants Into Spinal Cord
WebMD Feature
Reviewed by Laura J. Martin, MD

John Jerome's spinal cord shines white beneath the surgeons' headlamps, crisscrossed by a web of bright-red blood vessels. He's been on the operating table for more than four hours.

Above the fist-sized opening in his neck hangs a complex steel contraption. It's fixed in place by four posts: two wedged into Jerome's skull and two more in the vertebrae below the surgical wound. Invented by Emory neurosurgeon Nick Boulis, MD, it serves a single purpose: To hold steady the thin needle plunged into Jerome's spinal cord. If it breaks, it could kill him.

Understanding Stem Cells

Find out what stem cells do, what's happening in stem cell research, and what it may mean for you.

Stem Cells Special Report

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Stem Cells FAQ

A thin tube runs from the needle through the device and over to a small nearby table. At the table, concentrating intensely, Jonathan Glass, MD, is pumping stem cells into the tube from a small vial. On huge high-definition monitors, magnified images show Boulis plunge the needle directly into Jerome's naked spinal cord. The tube flexes. The doctors, nurses, technicians, and observers in the room hold their collective breath.

Glass counts down the time left in the infusion. Nobody speaks. The needle comes out. Boulis moves it a few millimeters, and coaxes it back into the spinal cord. Another vial of stem cells starts trickling through the tube.

A Deadly Disease

The journey that landed Jerome on that operating table started with a marathon. Like many runners training for a marathon, Jerome felt something go wrong with his stride -- and then there was this pain in his left knee. He underwent knee surgery, and the doctors told him the strength in his leg would return to normal.

It didn't. A year later, the same thing happened with his right leg. Over the next months Jerome's balance became less steady. And then his speech got noticeably slower. He checked his symptoms on WebMD. Then he made an appointment with a neurologist. He asked his wife, Donna, to come along.

"While he was doing some tests, he was kind of going, 'Mmmmm...,'" Jerome, 50, recalls, making that dreadful moaning sound you never want to hear from a doctor. "Then he goes, 'Well, I believe you have ALS, Lou Gehrig's disease .' I knew from going on WebMD I might have it. I hoped not. But that wasn't the case. It was devastating." He was 41 years old at the time.

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