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Brain & Nervous System Health Center

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Married ... With Lou Gehrig's Disease

WebMD Health News

May 5, 2000 -- First comes love, then comes marriage, then comes ... Lou Gehrig's disease? This seems to be true for nine married couples in France. In each case, both husband and wife have been diagnosed -- after years of marriage -- with the rare nerve disorder amyotrophic lateral sclerosis (ALS, more commonly known in this country as Lou Gehrig's disease.) Researchers studying these couples -- and their children -- hope to learn more about what part environment and genes play in this devastating disease. They presented their findings here at the 52nd annual meeting of the American Academy of Neurology.

ALS results in a gradual and ongoing destruction of the nerves that control the body's muscles. Symptoms include muscle weakness and cramping, uncontrollable twitching of the hands and feet, and slurred speech. As the disease progresses, it attacks nerves that connect to the muscles that control breathing - usually leading to death within 5 years of being diagnosed. According to the ALS Association, about 5,000 new cases are diagnosed in the U.S. each year, and there are 30,000 Americans with ALS at any given time.

The cause of ALS is unknown but is believed to be a combination of genes and environment. For example, a toxin sometimes used as a folk medicine by Pacific islanders has been associated with symptoms of ALS. Exposure to the virus that causes polio has also been suspected as a cause.

The French researchers, led by Philippe Corcia, MD, studied nine couples in which husband and wife both developed ALS. The couples ranged in age from 40 to 80 and lived together for an average of 20 years before coming down with the disease. When one spouse developed ALS, there was a lag time of 1-30 years before their partner began showing symptoms, but the average delay was 8 years.

Although husband-wife cases of Parkinson's and Huntington's diseases have been seen, this is the first report of marital ALS, says senior author William Camu, MD, a neurologist at the University of Montpellier, France. He explains that the occurrence is unlikely to be a coincidence.

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