Thalidomide for Lou Gehrig's Disease?
Tests on Mice Show Promise for Treating Amyotrophic Lateral Sclerosis
March 16, 2006 -- Tests on lab mice show that the drugs thalidomide and lenalidomide may help curb amyotrophic lateral sclerosis (ALS), widely called "Lou Gehrig's disease."
ALS is a progressive degenerative neurological disorder that has no cure. For reasons that aren't understood, the nerve cells of the brain and spinal cord that control voluntary muscle movement gradually deteriorate. As a result, muscles waste away, leading to paralysis and death, usually in two to five years.
ALS is often nicknamed "Lou Gehrig's disease" after the baseball player who died of ALS in 1941.
Thalidomide and lenalidomide showed promise in mice with ALS, the researchers report. However, they stress that they don't know yet if the same would be true for people.
The study appears in The Journal of Neuroscience.
About the Study
The researchers included Mahmoud Kiaei, PhD, of Cornell University's Weill Medical College.
Kiaei and colleagues didn't test the drugs on any people. But they did study samples of spinal cord tissue from 12 deceased people, half of whom had had ALS.
The tissue samples showed high levels of two inflammatory proteins. Those proteins -- called tumor necrosis factor alpha (TNF-alpha) and fibroblast-associated cell-surface ligand (FasL) -- both turned up in high levels in untreated mice with ALS.
The researchers split the mice into three groups. One group of mice got thalidomide, another group got lenalidomide, and the third group got injections of salt water, which has no medicinal use in ALS.
The researchers tested thalidomide and lenalidomide on the mice to see if those drugs would block the inflammatory proteins TNF-alpha and FasL.
The drugs appeared to have that effect. Levels of TNF-alpha and FasL fell in the mice treated with thalidomide and lenalidomide. Survival also improved and ALS worsened more slowly in the drug-treated mice.
However, much work lies ahead to see if the same is true for people.
"Drug metabolism and other factors are just so different between mice and humans," Kiaei says in a Cornell news release. "So far, none of what's worked for ALS in animal models has translated to effective treatments."
"Still, right now we have so little to offer patients in this devastating disease," Kiaei adds. "This does offer new hope."