Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Breast Cancer Health Center

Font Size

Gene Therapy Technique to Be Tested in People

WebMD Health News

June 9, 2000 (Atlanta) -- Researchers are looking for ways to use all the information that is coming out about the decoding of the human genetic system to cure many diseases. A successful gene therapy would make cancer cells their own worst enemies by causing them to produce a powerful molecule that marks the cells for destruction by the immune system.

The first human tests of the treatment are scheduled for later this year, Savio L.C. Woo, PhD, tells WebMD. Woo presented data from animal studies of the treatment here at the Department of Defense Breast Cancer Research Program Meeting.

The first patients in the study -- designed primarily to see whether the treatment is as safe in humans as it was in laboratory animals -- will be women whose breast cancer has spread to the liver. "If we validate the scientific principle that this works in the liver, there is no reason we can't deliver these genes to the other body sites where cancer has spread," says Woo, a researcher at New York's Mount Sinai School of Medicine.

The treatment uses a harmless virus to carry IL-12, a powerful human molecule that signals the immune system to attack whatever cell is carrying it. Because the virus carrying the gene is injected directly into the tumor, it can deliver a highly toxic dose of IL-12 without harming normal tissues around it.

In mice with breast cancer found in their livers, up to 40% survived after getting the IL-12 treatment, while all untreated mice died of cancer.

Even as human trials are being organized, the treatment has been improved. By adding another gene -- one that improves the functioning of part of the immune system -- the treatment becomes more than twice as effective. "We have increased long-term survival of animals from 20 to 40% to more than 80%," Woo says.

If the IL-12 gene therapy is safe in people, Woo says his team would likely seek approval for another study in which all patients would get the dose found most effective and least toxic in the first study. But in this second study, some patients also would get the additional gene.

Today on WebMD

Breast Cancer Overview
From self-exams and biopsies to reconstruction, we’ve got you covered.
Dealing with breast cancer
Get answers to your questions.
woman having mammogram
Experts don’t agree on all fronts, but you can be your own advocate.
woman undergoing breast cancer test
Many women worry. But the truth? Most abnormalities aren’t breast cancer.
Breast Cancer Treatments Improving
Resolved To Quit Smoking
Woman getting mammogram
Screening Tests for Women
ovarian cancer overview slideshow
serious woman
what is your cancer risk
10 Ways to Revitalize Slideshow