Femara Prevents Breast Cancer Recurrence
Drug Picks Up Where Tamoxifen Leaves Off in Reducing Cancer Risks
WebMD News Archive
How Femara Works
Femara is currently approved by the FDA as a primary treatment
for advanced breast cancer and as a secondary treatment for other types of
breast cancers. It's part of a class of drugs known as aromatase inhibitors
that work by suppressing estrogen production in the body.
Novartis, the pharmaceutical company that makes Femara, is a
WebMD sponsor. Other aromatase inhibitors include Arimidex and
Goss says that as breast cancer cells begin to outwit the
protective effects of tamoxifen therapy after long-term use, aromatase
inhibitors step in and reduce the risk of breast cancer recurrence by lowering
estrogen levels in the body and starving hormone-dependent breast cancer cells
of the estrogen they need to grow and survive.
Researchers say that even though postmenopausal women's bodies
have stopped producing estrogen, residual estrogen remains in fat and other
tissues that might eventually trigger a breast cancer recurrence.
Because Femara deprives the body of estrogen, it has also been
linked to an increased risk of osteoporosis and other hormone-related side
effects such as hot flashes. But researchers say the drug was well tolerated in
the study and these side effects were generally rare.
Harold Burstein, MD, PhD, a breast cancer specialist at
Dana-Farber Cancer Institute in Boston, says ongoing studies may eventually
show that other aromatase inhibitors provide similar breast cancer benefits as
Femara because the entire class of drugs works in the same way to deplete
"But in talking to patients right now, this is the drug to
be talking about because it is the only one for which we have data,"
Burstein tells WebMD. "I would not encourage people to think of other drugs
instead of this one."
Experts say that although these findings are remarkable, there
are still many questions about Femara that remain unanswered.
For example, because the study was stopped short, researchers
know little about the long-term risks of Femara use or the optimal duration of
Another issue is whether the thousands of breast cancer
survivors who have been off tamoxifen for more than three months would
experience the same benefits from starting therapy with Femara.
"We have no reason to believe they might not also benefit
from [Femara], but clearly further study is needed to know how long is too long
to consider [Femara]," says researcher James Ingle, MD, of the Mayo Clinic
in Rochester, Minn., who also spoke at the conference.
Ingle says the actual reduction in breast cancer recurrence
risk offered by Femara will vary greatly, depending on each woman's risk
factors, such as the size and aggressiveness of the primary tumor.
"Patients should sit down with their doctors to talk about
their specific situation," says Ingle.
Cost is also another factor to be considered, as Femara costs
about $6 per pill and coverage for treatment may vary according to insurance