Before getting her preventive (prophylactic) double mastectomy three and half weeks ago, Applegate had two lumpectomies -- and only had cancer in one breast, according to Good Morning America -- and took a gene test that showed that she had the BRCA1 gene mutation, which makes breast cancer and ovarian cancer more likely.
Applegate called her mastectomy decision "tough" but the "most logical" possibility for her. She said she based her choice on her family history -- her mother has had breast cancer and cervical cancer -- and her BRCA1 gene.
Is Applegate's approach to breast cancer one that would work for other breast cancer patients? And what will the reconstruction process -- for Applegate and for other women -- be like?
WebMD talked with four doctors -- and with a breast cancer survivor who made some of the same choices that Applegate did -- about preventive mastectomy and breast reconstructive surgery. None of the doctors who talked to WebMD are treating Applegate.
"I think she did the absolute right thing, and she did it the right way," says Jay Brooks, MD, FACP, chief of hematology/oncology and chief of staff at the Ochsner Health System in Baton Rouge, La.
"She underwent lumpectomy and then, when she got the information back from the genetic testing, she was able to have a little time to discern what this all meant and then she went forward to have the prophylactic mastectomies, which are clearly the best treatment to reduce her risk of ever developing breast cancer [again] by at least 90%," says Brooks.
"I think that's a very reasonable approach," says Brooks. "It may not be right for every patient, but I think especially if you have this genetic mutation -- it's such a highly active mutation in terms of increasing the risk of breast cancer -- that it's certainly something that I would recommend to one of my family members or to my patients, and I do," says Brooks, noting that only about 5% to 7% of breast cancer patients have cases similar to Applegate's.