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    Canola Oil May Affect Breast Cancer Risk

    Study Shows Potential Benefit for Offspring When Canola Oil Is Consumed During Pregnancy
    By
    WebMD Health News
    Reviewed by Louise Chang, MD

    Nov. 18, 2008 -- Could the type of oil a woman consumes during pregnancy influence her daughter's breast cancer risk years later?

    Early research in mice suggests that it might -- and that pregnant women may be better off choosing canola oil over most other vegetable oils.

    Canola oil has more omega-3 fatty acids and less omega-6 than other widely used cooking oils.

    "We showed that canola oil in the maternal diet during pregnancy and nursing reduced the risk for breast cancer in babies for up to five months after birth," researcher W. Elaine Hardman, PhD, of Marshall University School of Medicine, tells WebMD.

    The research was presented today in Washington D.C. at the American Association for Cancer Research's Seventh Annual International Conference on Frontiers in Cancer Prevention Research.

    Canola Oil vs. Corn Oil

    "Corn oil has 50% omega-6 and almost no omega-3, while canola oil has 20% omega-6 and 10% omega-3," Hardman says. "Flaxseed oil is 50% omega-3, but you wouldn't want to cook with it. It tastes pretty bad. Canola is about the best cooking oil out there in terms of omega-6 to omega-3 ratio."

    In the newly reported study, the mothers of mice genetically engineered to develop breast cancer were fed diets that contained either 10% canola oil or 10% corn oil for several weeks prior to breeding up until the time their offspring were weaned.

    Following weaning, the offspring were fed the corn-oil rich diet.

    Throughout the study, the female mice born to the mothers fed corn oil had more breast tumors and bulkier tumors than the mice born to mothers who followed the canola-oil diet. They also had tumors in more mammary glands.

    This was particularly significant because on a regular diet the genetically engineered mice could be expected to develop breast cancer by 6 months of age, Hardman says.

    But mice aren't people, and the findings fall far short of proving that women can protect their unborn daughters from breast cancer or increase their daughters' risk by choosing a particular cooking oil, American Cancer Society nutritional epidemiologist Margie McCullough, ScD, tells WebMD.

    "This finding is intriguing, but many important questions remain," she says.

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