BP Drug Blocks Newly Found Breast Cancer Gene
Blood Pressure Drug Losartan Shrinks Cancer Tumors by 30% in Study
Developing a Test for AGTR1-Positive Tumors
But if there were a study in which losartan were given only to women with breast cancers linked to overexpression of AGTR1, it would be much easier to detect an effect. Before such a trial can be set up, however, scientists must first develop a way to easily detect AGTR1 overexpression.
Once that test is available -- something that should take only a few months, says Rhodes -- a clinical trial should be easier than usual to set up because of the availability of an existing, approved therapy whose side effects are known. “No trial is specifically planned yet, but we are talking with our clinical colleagues about it and there is a great deal of interest,” he says.
“If the data can be confirmed, it’s not a big stretch to imagine setting up a randomized study relatively easily,” Hudis says. “I definitely think this should be investigated further, although as always when we don’t yet have data in humans, you have to be careful and not jump to conclusions.”
The University of Michigan has filed a patent on AGTR1 and is seeking commercial partners.