Ear Wax, Body Odor: Breast Cancer Link?
Researchers See Clues for Breast Cancer Risk in Underarm Body Odor and Wet Ear Wax
June 5, 2009 -- A variation in a gene already associated with breast cancer risk is also linked with especially unpleasant underarm body odor and wet ear wax, according to a team of Japanese scientists.
The discovery is not meant to make women with either condition anxious, says Toshi Ishikawa, PhD, professor of biomolecular engineering at the Tokyo Institute of Technology and the senior author of the study. Rather, he says, "we do strongly hope that our study will provide a new tool for better prediction of breast cancer risk" by using a new method of finding the variation developed by his team.
Having wet ear wax or excessively smelly armpits does not mean a woman is destined to get breast cancer, Ishikawa says. "To be clear, I should strongly mention that the [specific gene variation found to link body odor, wet ear wax, and breast cancer risk] is one factor that increases breast cancer risk," Ishikawa says. "And it might have to work in tandem with something else -- such as environmental factors and mutations of tumor suppressor genes such as BRCA1, BRCA2, p53, and so on."
Ishikawa's team extracted DNA from blood samples provided by 124 volunteers at Nagasaki University in Japan.
They studied a gene called ABCC11, discovered by them and others in 2001. Variations in the gene have been found to be associated with increased breast cancer risk. These variations, called SNPs ("snips") or single nucleotide polymorphisms, occur when a single nucleotide or molecule in an individual's genome sequence changes. SNPs are common in the population.
While many SNPs don't affect the way cells function, experts think that other variations may predispose people to specific diseases such as cancer or affect the way they respond to a medication.
In this study, Ishikawa monitored the activities of a protein created by the ABCC11 gene, finding a distinct link between the ABCC11 gene and having extremely smelly underarm odor and wet, sticky earwax.
Then they figured out the cellular mechanisms that control wet ear wax, excessively bad underarm odor, and breast cancer risk.
They developed a rapid method of typing this SNP in the DNA sequence associated with the higher risk for the three conditions. It can be done in 30 minutes.
The study is published in The FASEB Journal.