Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started
My Medicine

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Breast Cancer Health Center

Font Size

Why Women Choose Preventive Mastectomy

Study Shows Women With Gene Mutations Are Among Those Who Choose Preventive Surgery
WebMD Health News
Reviewed by Louise Chang, MD

Aug. 6, 2009 -- For women at high risk of breast cancer, deciding whether to get preventive mastectomy boils down to knowing how high their "high risk" level is.

That's according to a new British study of some 3,500 women at high risk of breast cancer.

Those women had at least a 25% lifetime risk of developing breast cancer. That means that at least a quarter of them would likely develop breast cancer sometime during their lives.

For comparison, the lifetime breast cancer risk for U.S. women is 12%, according to the National Cancer Institute. Breast cancer risk varies from woman to woman, based on many breast cancer risk factors.

In the new study, 211 women knew they had BRCA1 or BRCA2 gene mutations, putting them at very high risk of breast cancer and ovarian cancer. The other women didn't know if they had the BRCA1 or BRCA2 gene mutations.

Each woman was counseled about her breast cancer risk and about the option of prophylactic mastectomy, which is surgery to remove both breasts while they're still cancer-free. Women with the BRCA1 or BRCA2 gene mutations could also get surgery to remove their ovaries, in light of their ovarian cancer risk.

The women were free to choose surgery or not, and they could take as long as they wanted to make that decision.

Women with BRCA1 or BRCA2 gene mutations, women at very high risk of breast cancer, and women ages 35-45 were the most likely to choose preventive mastectomy.

Among women with BRCA1 or BRCA2 gene mutations, those age 35-45 were the most likely to choose surgery to remove their ovaries. Younger women may delay that until after they're done having children, note the researchers, who included D. Gareth Evans, MD, a professor at England's University of Manchester.

In some cases, the decision to get prophylactic mastectomy took many years.

"Women have their breasts or ovaries removed based on their risk. It does not always happen immediately after counseling or a genetic test result and can take more than seven years for patients to decide to go forward with the surgery," Evans says in a news release.

The study doesn't show why the women chose to get, delay, or skip preventive surgery. It's a balancing act between their cancer risk, cancer fears, life stage, and other commitments, write Evans and colleagues.

The U.K.'s national health care system covered genetic testing and the women's operations. It's not clear if the study's findings apply to women in other countries.

Today on WebMD

Breast Cancer Overview
From self-exams and biopsies to reconstruction, we’ve got you covered.
Dealing with breast cancer
Get answers to your questions.
woman having mammogram
Experts don’t agree on all fronts, but you can be your own advocate.
woman undergoing breast cancer test
Many women worry. But the truth? Most abnormalities aren’t breast cancer.
Breast Cancer Treatments Improving
Resolved To Quit Smoking
Woman getting mammogram
Screening Tests for Women
ovarian cancer overview slideshow
serious woman
what is your cancer risk
10 Ways to Revitalize Slideshow