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Longer HRT Use May Raise Breast Cancer Risk

Study Also Shows Higher Risk for Thinner Women Who Take Hormone Replacement Therapy

Second Opinion

The new analysis has findings that differ from other clinical trials, such as the Women's Health Initiative (WHI), says Rowan Chlebowski, MD, PhD, a medical oncologist at the LA Biomedical Research Institute in Torrance, Calif., and an investigator for WHI. But that's to be expected, he says, given the design of the two approaches.

The WHI, launched in 1991, included clinical trials and observational studies and tested hormone therapy and other interventions on the risks of heart disease, fractures, and breast and colorectal cancers.

For instance, in the WHI, long-term estrogen-only use, at least initially, reduced the risk of breast cancer, Chlebowski says.

But when it comes to practical decisions, the new analysis, Chlebowski tells WebMD, "probably doesn't change things too much."

For menopausal women, he says, the message is to take hormone therapy if needed to relieve menopausal symptoms for a time. "After a period of time, like a couple of years, reassess," he says.

According to the American Congress of Obstetricians and Gynecologists, a woman should take the smallest dose of hormone therapy that works for her, for the shortest possible time.

"This [finding] doesn't change the message," he says. And that is that the primary reason to take hormone therapy is for relief of menopausal symptoms, not long-term protection from disease.

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