Skip to content

    Breast Cancer Health Center

    Font Size

    Obesity May Affect Breast Cancer Recovery

    Study Ties Extra Pounds to a Higher Risk of Cancer Recurrence, Early Death
    WebMD Health News
    Reviewed by Louise Chang, MD

    Aug. 27, 2012 -- Extra pounds may raise the risk for recurrence among women with the most common kind of breast cancer, a new study shows.

    Prior studies have found that being overweight or obese increases the risk of getting a number of cancers, including breast cancer. And smaller studies have noted that obese breast cancer patients tended to fare worse than those who are normal weight.

    The new study takes a fresh look at data collected on more than 7,000 breast cancer patients who were enrolled in three government-sponsored clinical trials.

    The trials were originally designed to test the effectiveness of different combinations of chemotherapy drugs. All the women in the studies had operable cancers without spread to distant organs and received cutting-edge treatment for their cancers.

    As Body Weight Climbs, So Does the Risk

    Despite that, a woman’s weight was still linked to the likelihood that she might beat the disease.

    Among women with hormone-sensitive tumors, those who were overweight or obese when they were diagnosed were about 30% more likely than those with normal body weights to see their breast cancers come back after surgery and chemotherapy. They were also about 50% more likely to die over the course of the studies.

    The risk appeared to increase in a step-wise fashion -- the higher a woman’s weight, the greater her odds of recurrence and early death.

    The study doesn’t prove that too much body fat causes cancer directly. But as scientists learn more about fat, they think that’s a strong possibility.

    Fat cells play a role in the production of hormones like estrogen and insulin that spur the growth of tumors. Fat also increases inflammation, another cancer driver, says researcher Joseph A. Sparano, MD, associate chairman of medical oncology at the Montefiore Einstein Center for Cancer Care in New York City.

    What it means, simply, is “the more you weigh, the worse the outcome,” says Stefan Gluck, MD, a professor of medicine and a breast oncologist at the University of Miami’s Sylvester Comprehensive Cancer Center. He was not involved in the research.

    Today on WebMD

    Breast Cancer Overview
    From mammograms to living after treatment.
    Dealing with breast cancer
    Get answers to your questions.
    woman having mammogram
    The 3 latest tips to know.
    woman undergoing breast cancer test
    Most abnormalities aren’t breast cancer.
    Resolved To Quit Smoking
    Breast Cancer Treatments Improving
    Woman getting mammogram
    Screening Tests for Women
    serious woman
    Pink badge on woman chest to support breat cancer
    what is your cancer risk
    breast cancer survivors