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Breast Cancer Drug Herceptin Linked to Heart Risks

But most of these effects reverse after women finish treatment, experts say


After stopping the drug, the blood pumping problems resolved in more than 87 percent of the two-year group and more than 81 percent of the one-year group.

The new findings reaffirm previous research with shorter follow-up times, said Dr. Joanne Mortimer, director of Women's Cancer Programs and co-director of the Breast Cancer Program at City of Hope Cancer Center in Duarte, Calif. She reviewed the findings but was not involved in the study.

The new study reaffirms that the heart problems linked with the drug don't increase with time, she said, "and that's what is important."

"There's no question this is a really important drug," Mortimer said, as previous studies have shown trastuzumab to improve survival from this more aggressive form of breast cancer.

Doctors know that women with a history of high blood pressure and those over 65 are at higher risk of heart problems while on the drug, she said.

Women should have a cardiac assessment before starting trastuzumab, Leyland-Jones said, and should have cardiac monitoring while they are taking it so that any cardiac problems related to the drug can be found and treated early.


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