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Breast Cancer Health Center

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Genetics of Breast and Ovarian Cancer (PDQ®): Genetics - Health Professional Information [NCI] - Psychosocial Issues in Inherited Breast and Ovarian Cancer Syndromes

Table 14. Uptake of Risk-reducing Mastectomy (RRM) and/or Breast Screening AmongBRCA1andBRCA2Mutation Carriers

Study CitationStudy PopulationUptake of RRMUptake of Breast Screening Mammography and/or Breast MRILength of Follow-upComments
MRI = magnetic resonance imaging; RRSO = risk-reducing salpingo-oophorectomy.
a Self-report as data source.
b Medical records as data source.
United States
Botkin et al. (2003)[216]Carriers (n = 37)aCarriers 0%Mammography24 mo
- Carriers 57%
Noncarriers (n = 92)aNoncarriers 0%- Noncarriers 49%
- Declined test 20%
Declined testing (n = 15)aMRI
- Not evaluated
Beattie et al. (2009)[217]Carriers (n = 237)bCarriers 23%Not applicableMean, 3.7 yWomen opting for RRM were younger than 60 y, had a prior diagnosis of breast cancer, and also underwent RRSO.
Median time to RRM: 124 days from receiving results.
O'Neill et al. (2010)[218]Carriers (n = 146)aCarriers 13%Not applicable12 moIntentions at test result disclosure predicted RRM decisions.
Schwartz et al. (2012)[219]Carriers (n = 108)aCarriers 37%MammographyMean, 5.3 yPredictors of RRM were younger age, higher precounseling cancer distress, more recent diagnosis of breast or ovarian cancer, and intact ovaries.
- Carriers affected 92%
- Carriers unaffected 82%
Noncarriers (n = 60)aNoncarriers 0%- Noncarriers 66%
- Uninformative affected 89%
Uninformative (n = 206)aUninformative 6.8%- Carriers affected 51%
- Carriers unaffected 46%
- Noncarriers 11%
- Uninformative 27%
Garcia et al. (2013)[220]Carriers (n = 250)bCarriers 44%Excluding women post RRM:41 months; range, 26-66 moBreast surveillance decreased significantly from y 1-5 of follow-up: Mammography 43% to 7%; MRI 35% to 3%.
- Carriers 43%
- Carriers 35%
Singh et al. (2013)[221]Carriers (n = 136)bCarriers 42%Not applicableRange, 1-11 yPredictors of RRM were first- or second-degree relative diseased from breast cancer, having had at least one childbirth, and having undergone testing after 2005.
Phillips et al. (2006)[222]Carriers (n = 70)aCarriers 11%Mammography3 y
- Carriers 89%
- Not evaluated
Metcalfe et al. (2008)[223]Carriers (N = 2,677)aCarriers 18% (unaffected)Mammography3.9 y; range, 1.5-10.3 yLarge differences in uptake of risk management options by country.
- Carriers 87%
MRI1,294 participants had a personal history of breast cancer.
- Carriers 31%
Julian-Reynier et al. (2011)[224]Carriers (n = 101)aCarriers 6.9%Mammography5 yNoncarriers often continued screening.
- Carriers 59%
- Noncarriers aged 30-39 y 53%
Noncarriers (n = 145)aNoncarriers 0%MRI
- Carriers 31%
- Noncarriers 4.8%
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