Each year in the United States, close to 250,000 women learn they have breast cancer. As they deal
with their diagnosis, they are also asked to make daunting decisions about how
to best fight their disease.
New patients facing treatment need to understand their options, and that
means learning all they can about their cancer, says breast cancer
surgeon Lee Gravatt Wilke, MD.
Wilke, who is an assistant professor of surgery at Duke University Health
System and a board member of the NavigateCancer...
Treatment for men diagnosed with breast cancer is usually modified radical mastectomy. Breast-conserving surgery with lumpectomy may be used for some men.
Therapy given after an operation when cancer cells can no longer be seen is called adjuvant therapy. Even if the doctor removes all the cancer that can be seen at the time of the operation, the patient may be given radiation therapy, chemotherapy, hormone therapy, and/or targeted therapy after surgery, to try to kill any cancer cells that may be left.
Node-negative: For men whose cancer is node-negative (cancer has not spread to the lymph nodes), adjuvant therapy should be considered on the same basis as for a woman with breast cancer because there is no evidence that response to therapy is different for men and women.
Node-positive: For men whose cancer is node-positive (cancer has spread to the lymph nodes), adjuvant therapy may include the following:
A clinical trial of targeted therapy with a monoclonal antibody (trastuzumab).
These treatments appear to increase survival in men as they do in women. The patient's response to hormone therapy depends on whether there are hormone receptors (proteins) in the tumor. Most breast cancers in men have these receptors. Hormone therapy is usually recommended for male breast cancer patients, but it can have many side effects, including hot flashes and impotence (the inability to have an erection adequate for sexual intercourse).
Treatment for men with distant metastases (cancer that has spread to other parts of the body) may be hormone therapy, chemotherapy, or both. Hormone therapy may include the following:
Orchiectomy (the removal of the testicles to decreasehormone production).
Luteinizing hormone-releasing hormone agonist with or without total androgen blockade (to decrease the production of sex hormones).
Tamoxifen for cancer that is estrogen-receptor positive.
Aromatase inhibitors (to lessen the amount of estrogen produced).
Hormone therapies may be used in sequence (one after the other). Standard chemotherapy regimens may be used if hormone therapy does not work. Men usually respond to therapy in the same way as women who have breast cancer.
In this article
This information is produced and provided by the National
Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National
Institute via the Internet web site at http://
.gov or call 1-800-4-CANCER.
WebMD Public Information from the National Cancer Institute
February 25, 2014
This information is not intended to replace the advice of a doctor.
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