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    Adult Brain Tumors Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Changes to This Summary (02 / 28 / 2014)

    The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above.

    General Information About Adult Brain Tumors

    Recommended Related to Brain Cancer

    Brain Cancer Clinical Trials

    Major pharmaceutical companies continually research and develop new medications and treatments for brain cancer, which must be shown to be safe and effective before doctors can prescribe them to patients. Through clinical trials, researchers test the effects of new medications on a group of volunteers with brain cancer. Following a strict protocol and using carefully controlled conditions, researchers evaluate the investigational drugs under development and measure the ability of the new drug to...

    Read the Brain Cancer Clinical Trials article > >

    Updated statistics with estimated new cases and deaths for 2014 (cited American Cancer Society as reference 1).

    Treatment Option Overview

    Added text to state that the natural histories of these tumors are variable, depending on histological and molecular factors; therefore, treatment guidelines are evolving. Also revised text to state that therapy involving surgically implanted carmustine-impregnated polymer wafers combined with postoperative external-beam radiation therapy may play a role in the treatment of high-grade gliomas (grade III and IV gliomas) in some patients.

    Management of Specific Tumor Types and Locations

    Revised the Glioblastomas subsection extensively.

    Revised text to state that patients who have oligodendrogliomas (WHO grade II) generally have a better prognoses than do patients who have diffuse astrocytomas; however, most of the oligodendrogliomas eventually progress.

    Added text to include stereotactic radiosurgery for tumors less than 3 cm as a standard treatment option for grade 1 meningiomas and revised a treatment option to read fractionated radiation therapy for patients with resectable tumors.

    Recurrent Adult Brain Tumors

    Added Bevacizumab as a new subsection.

    Revised text to add lomustine as an additional systemic chemotherapy drug.

    This summary is written and maintained by the PDQ Adult Treatment Editorial Board, which is editorially independent of NCI. The summary reflects an independent review of the literature and does not represent a policy statement of NCI or NIH. More information about summary policies and the role of the PDQ Editorial Boards in maintaining the PDQ summaries can be found on the About This PDQ Summary and PDQ NCI's Comprehensive Cancer Database pages.

    This information is produced and provided by the National Cancer Institute (NCI). The information in this topic may have changed since it was written. For the most current information, contact the National Cancer Institute via the Internet web site at http:// cancer .gov or call 1-800-4-CANCER.

    WebMD Public Information from the National Cancer Institute

    Last Updated: 8/, 015
    This information is not intended to replace the advice of a doctor. Healthwise disclaims any liability for the decisions you make based on this information.
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