Treatment Options for Recurrent Diffuse Intrinsic Pontine Gliomas (DIPGs)
Given the dismal prognosis for patients with DIPGs, progression of the pontine lesion is anticipated generally within 1 year of completing radiation therapy. In most cases, biopsy at the time of clinical or radiologic progression is neither necessary nor recommended. To date, no salvage regimen has been shown to extend survival. Patients should be considered for entry into trials of novel therapeutic approaches because there are no standard agents that have demonstrated a clinically significant activity.
A meningioma is a tumor that forms on membranes that cover the brain and spinal cord just inside the skull.
Specifically, the tumor forms on the three layers of membranes that are called meninges.
These tumors are often slow-growing. As many as 90% are benign (not cancerous).
Most meningiomas occur in the brain. But they can also grow on parts of the spinal cord.
Often, meningiomas cause no symptoms and require no immediate treatment. But the growth of benign meningiomas can cause serious problems...
Palliative care is provided for these patients whether or not disease-directed therapy is administered.
Treatment options under clinical evaluation
Early-phase therapeutic trials may be available for selected patients. These trials may be available via Children's Oncology Group phase I institutions, the Pediatric Brain Tumor Consortium, or other entities.
Treatment Options for Recurrent Focal or Low-Grade Brain Stem Gliomas
At the time of recurrence, a complete evaluation to determine the extent of the relapse may be indicated for selected low-grade lesions. Biopsy or surgical resection should be considered for confirmation of relapse when other entities such as secondary tumor and treatment-related brain necrosis, which may be clinically indistinguishable from tumor recurrence, are in the differential diagnosis. Other tests, including positron emission tomography, magnetic resonance spectroscopy, and single-photon emission computed tomography, have not yet been shown to be reliable in distinguishing necrosis from tumor recurrence in brain stem gliomas. Radiation-induced changes may occur a few months after the completion of radiation therapy and may mimic tumor progression. When considering the efficacy of additional treatment, care needs to be taken to separate radiation-induced change from progressive disease.
Treatment considerations at the time of recurrence or progression are dependent on prior treatment. Treatment options for recurrent focal or low-grade brain stem gliomas include the following:
Repeat surgical resection: The need for surgical intervention must be individualized on the basis of the initial tumor type, the location within the brain stem, the length of time between initial treatment, the appearance of the mass lesion, and the clinical picture.
Radiation therapy including 3-dimensional conformal radiation therapy.