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Cervical Cancer Health Center

Medical Reference Related to Cervical Cancer

  1. Cervical Cancer Screening (PDQ®): Screening - Patient Information [NCI] - Stage I Endometrial Cancer

    Standard treatment options: A total hysterectomy and bilateral salpingo-oophorectomy should be done if the tumor: Is well or moderately differentiated.Involves the upper 66% of the corpus.Has negative peritoneal cytology.Is without vascular space invasion.Has less than a 50% myometrial invasion.Selected pelvic lymph nodes may be removed. If they are negative, no postoperative treatment is indicated. Postoperative treatment with a vaginal cylinder is advocated by some clinicians.[1]For all other cases and cell types, a pelvic and selective periaortic node sampling should be combined with the total hysterectomy and bilateral salpingo-oophorectomy, if there are no medical or technical contraindications. One study found that node dissection per se did not significantly add to the overall morbidity from hysterectomy.[2] While the radiation therapy will reduce the incidence of local and regional recurrence, improved survival has not been proven and toxic effects are

  2. Cervical Cancer Screening (PDQ®): Screening - Patient Information [NCI] - Low-Risk Gestational Trophoblastic Neoplasia (FIGO Score 0–6) Treatment

    There is no consensus on the best chemotherapy regimen for initial management of low-risk gestational trophoblastic neoplasia (GTN), and first-line regimens vary by geography and institutional preference. Most regimens have not been compared head-to-head, and the level of evidence for efficacy is often limited to 3iiDii except as noted below. Even if there are differences in initial remission rate among the regimens, salvage with alternate regimens is very effective, and the ultimate cure rates are generally 99% or more. The initial regimen is generally given until a normal beta human chorionic gonadotropin (beta-hCG) (for the institution) is achieved and sustained for 3 consecutive weeks (or at least for one treatment cycle beyond normalization of the beta-hCG). A salvage regimen is instituted if any of the following occur:A plateau of the beta-hCG for 3 weeks (defined as a beta-hCG decrease of 10% or less for 3 consecutive weeks).A rise in beta-hCG of greater than 20%

  3. Cervical Cancer Screening (PDQ®): Screening - Patient Information [NCI] - Stage III Uterine Sarcoma

    Standard treatment options:Surgery (total abdominal hysterectomy, bilateral salpingo-oophorectomy, pelvic and periaortic selective lymphadenectomy, and resection of all gross tumor).Treatment options under clinical evaluation:Surgery plus pelvic radiation therapy.Surgery plus adjuvant chemotherapy. Carcinosarcomas (the preferred designation by the World Health Organization) are also referred to as mixed mesodermal or mullerian tumors. Controversy exists about the following issues:Whether they are true sarcomas.Whether the sarcomatous elements are actually derived from a common epithelial cell precursor that also gives rise to the usually more abundant adenocarcinomatous elements. The stromal components of the carcinosarcomas are further characterized by whether they contain homologous elements (such as malignant mesenchymal tissue considered possibly native to the uterus) or heterologous elements (such as striated muscle, cartilage, or bone, which are foreign to the uterus).

  4. Cervical Cancer Screening (PDQ®): Screening - Patient Information [NCI] - Stages IIB, III, and IVA Cervical Cancer Treatment

    Either radiation therapy or radical hysterectomy results in cure rates of 75% to 80%. The selection of either option depends on patient factors and local expertise. A randomized trial reported identical 5-year overall survival (OS) and disease-free survival rates when radiation therapy was compared with radical hysterectomy.[1] The size of the primary tumor is an important prognostic factor and should be carefully evaluated in choosing optimal therapy.[2] For patients with bulky (>6 cm) endocervical squamous cell carcinomas or adenocarcinomas, treatment with high-dose radiation therapy will achieve local control and survival rates comparable to treatment with radiation therapy plus hysterectomy. Surgery after radiation therapy may be indicated for some patients with tumors confined to the cervix that respond incompletely to radiation therapy or in whom vaginal anatomy precludes optimal brachytherapy.[3] After surgical staging, patients found to have small volume para-aortic nodal

  5. Cervical Cancer Screening (PDQ®): Screening - Patient Information [NCI] - Questions or Comments About This Summary

    If you have questions or comments about this summary, please send them to through the Web site's Contact Form. We can respond only to email messages written in English.

  6. Cervical Cancer Screening (PDQ®): Screening - Patient Information [NCI] - Treatment Option Overview

    There are different types of treatment for patients with gestational trophoblastic disease.Different types of treatment are available for patients with gestational trophoblastic disease. Some treatments are standard (the currently used treatment), and some are being tested in clinical trials. Before starting treatment, patients may want to think about taking part in a clinical trial. A treatment clinical trial is a research study meant to help improve current treatments or obtain information on new treatments for patients with cancer. When clinical trials show that a new treatment is better than the standard treatment, the new treatment may become the standard treatment.Clinical trials are taking place in many parts of the country. Information about ongoing clinical trials is available from the NCI Web site. Choosing the most appropriate cancer treatment is a decision that ideally involves the patient, family, and health care team.Three types of standard treatment are

  7. Cervical Cancer Screening (PDQ®): Screening - Patient Information [NCI] - General Information About Gestational Trophoblastic Disease

    Gestational trophoblastic disease (GTD) is a group of rare diseases in which abnormal trophoblast cells grow inside the uterus after conception.Gestational trophoblastic disease (GTD) develops inside the uterus from tissue that forms after conception (the joining of sperm and egg). This tissue is made of trophoblast cells and normally surrounds the fertilized egg in the uterus. Trophoblast cells help connect the fertilized egg to the wall of the uterus and form part of the placenta (the organ that passes nutrients from the mother to the fetus).Sometimes there is a problem with the fertilized egg and trophoblast cells. Instead of a healthy fetus developing, a tumor forms. Until there are signs or symptoms of the tumor, the pregnancy will seem like a normal pregnancy.Most GTD is benign (not cancer) and does not spread, but some types become malignant (cancer) and spread to nearby tissues or distant parts of the body.Gestational trophoblastic disease (GTD) is a general term that

  8. Cervical Cancer Screening (PDQ®): Screening - Patient Information [NCI] - Changes to This Summary (08 / 22 / 2013)

    The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above. Editorial changes were made to this summary.

  9. Cervical Cancer Screening (PDQ®): Screening - Patient Information [NCI] - About This PDQ Summary

    No standard treatment is available for patients with recurrent cervical cancer that has spread beyond the confines of a radiation or surgical field. For locally recurrent disease, pelvic exenteration can lead to a 5-year survival rate of 32% to 62% in selected patients.[1,2] These patients are appropriate candidates for clinical trials testing drug combinations or new anticancer agents. The Gynecologic Oncology Group (GOG) has reported on several randomized phase III trials, (GOG-0179 [NCT00003945], GOG-0240 [NCT00803062]) in this setting. Single-agent cisplatin administered intravenously at 50 mg/m² every 3 weeks was the most-used regimen to treat recurrent cervical cancer since it was initially introduced in the 1970s.[3,4]Various combinations containing cisplatin [3,4] failed to reach their primary endpoint of improving survival, however, a doubling of the cisplatin dose-rate did improve survival. Combinations with paclitaxel and with ifosfamide improved response rates

  10. Cervical Cancer Screening (PDQ®): Screening - Patient Information [NCI] - Changes to This Summary (12 / 02 / 2013)

    The PDQ cancer information summaries are reviewed regularly and updated as new information becomes available. This section describes the latest changes made to this summary as of the date above. Editorial changes were made to this summary.

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