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    Early Uterine Cancer: Radiation Helps

    After Hysterectomy, Radiation Raises Stage I Endometrial Cancer Survival

    Survival

    Radiation therapy boosted survival for women at all ages. But the exact benefit differed with age.

    For women younger than 56:

    • For stage IC/grade 1 disease, 5-year overall survival improved from 88% to 98%.
    • For stage IC/grade 1 disease, 10-year overall survival improved from 69% to 92%.
    • For stage IC/grade 3-4 disease, 5-year overall survival improved from 77% to 86%.
    • For stage IC/grade 3-4 disease, 10-year overall survival improved from 77% to 86% (the same as 5-year survival).

    For women aged 56-75:

    • For stage IC/grade 1 disease, 5-year overall survival improved from 85% to 94%.
    • For stage IC/grade 1 disease, 10-year overall survival improved from 72% to 76%.
    • For stage IC/grade 3-4 disease, 5-year overall survival improved from 56% to 66%.
    • For stage IC/grade 3-4 disease, 10-year overall survival improved from 42% to 51%.

    For women older than 75:

    • For stage IC/grade 1 disease, 5-year overall survival improved from 67% to 84%.
    • For stage IC/grade 1 disease, 10-year overall survival improved from 42% to 59%.
    • For stage IC/grade 3-4 disease, 5-year overall survival improved from 39% to 53%.
    • For stage IC/grade 3-4 disease, 10-year overall survival improved from 11% to 27%.

    Doctors Know More Than Statistics

    Lee and colleagues note that statistics help doctors and patients make treatment decisions. But they aren't a substitute for doctors' knowledge of their patients.

    "Statistical analysis cannot replace clinical judgment when considering the individual patient, tumor characteristics, and the potential risks and benefits of radiation therapy," they write.

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