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Cervical Cancer Health Center

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Gardasil Linked to Nerve Disorder

Cervical Cancer Vaccine May Raise Risk of Guillain-Barre Syndrome
WebMD Health News
Reviewed by Louise Chang, MD

April 30, 2009 (Seattle) -- Girls and women who receive the Gardasil vaccine to prevent cervical cancer may be at increased risk of a rare but serious disorder of the nervous system in the first few weeks after getting their shots, researchers report.

Overall, the vaccine does not raise the odds of developing Guillain-Barre syndrome (GBS), a disorder of the peripheral nervous system, says Nizar Souayah, MD, of the University of Medicine and Dentistry of New Jersey in Newark.

“But there is clear evidence from our database of an increased incidence of Guillain-Barre syndrome in the first six weeks, especially the first two weeks, after vaccination,” he tells WebMD.

Still, the risk is extremely low: 26 in 10 million in the first two weeks and 30 in 10 million in the first six weeks after vaccination. That compares to 5 in 10 million odds in the general population, Souayah says.

In response to the study, a spokesperson for Merck, which makes Gardasil, notes that the CDC says that “the data do not currently suggest an association between Gardasil and GBS.”

The findings were presented at the annual meeting of the American Academy of Neurology.

Guillain-Barre Syndrome and Vaccination

Guillain-Barre syndrome is a rare nervous system disorder in which the body's immune system attacks part of the nervous system. This immune system malfunction is usually triggered by an infection, such as with flu virus, or other illness. Occasionally, surgery or vaccinations will trigger the syndrome.

The link between Guillain-Barre syndrome and vaccinations isn't clear. But researchers say concerns emerged after an association was noticed during the 1976-1977 "swine flu" season. Since then, “there is always a concern when any vaccine program is introduced,” says Ken Gorson, MD, a neurologist at Tufts University/St. Elizabeth’s Medical Center in Boston.

In January 2007, the CDC added Gardasil to its routine childhood immunization schedule. The CDC recommended Gardasil for all girls aged 11-12 and even for girls as young as 9, with catch-up doses for girls and women 13-26 who hadn't been vaccinated earlier.

HPV is a sexually transmitted virus, with dozens of strains.

As of December 2008, more than 23 million doses of the vaccine were distributed, according to Souayah.

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