The stage determines the extent of cancer growth in and
beyond the uterus. Staging is done when the uterus is removed (hysterectomy). The surgeon will examine the other
pelvic organs to look for signs of cancer and remove them if necessary.
grade of endometrial cancer refers to how the cancer cells look under a
microscope. Learning the grade can help your doctor decide which treatments will work best for you.
Endometrial cancer has been classified by the American Joint
Committee on Cancer (AJCC) and the Fédération Internationale de Gynécologie et
d’Obstétrique (FIGO, also called the International Federation of Gynecology and
Obstetrics). The two classification systems are very similar.1
Note: Some citations in the text of this section are followed by a level of evidence. The PDQ Editorial Boards use a formal ranking system to help the reader judge the strength of evidence linked to the reported results of a therapeutic strategy. (Refer to the PDQ summary on Levels of Evidence for more information.)
Patients with stage I and II disease have an excellent prognosis, regardless of histology. A Children's Cancer Group study demonstrated that pulsed chemotherapy with cyclophosphamide,...
T3b (Stage IIIB). Tumor has spread
(metastasized) into the tissue layers of the
T4 (Stage IVA). Tumor has spread into the bladder or rectum.
After the tumor (T) is staged, the TNM system stages
lymph node involvement (N) to help determine the
treatment options at each stage. Lymph node involvement is staged in the
NX. Lymph nodes near the
primary tumor cannot be evaluated.
Cancer has not spread to lymph nodes near the primary tumor.
N1 (IIIC1). Cancer has spread to lymph nodes near the primary
N2 (IIIC2). Cancer has spread to the lymph nodes near the aorta, with or without spreading to the pelvic lymph nodes.
The last part of staging endometrial cancer is to find out whether
cancer has spread to other areas of the body (metastasized). The TNM system
stages metastasis (M) in the following way:
M0. No distant
metastasis is found.
M1 (IVB). Metastasis to
another area of the body has occurred, but not to the vagina, to the pelvic membranes and adjoining tissue, or to the lymph nodes near the aorta.
The TNM staging system allows your doctor to recommend
the most effective treatment options and discuss the long-term outcome
(prognosis) based on the type of tumor, the stage of your cancer, your age and
overall health condition.
The FIGO stages and the AJCC TNM class are grouped in the following
Classification of endometrial cancer
Tis, N0, M0
T1, N0, M0
T1a, N0, M0
T1b, N0, M0
T2, N0, M0
T3, N0, M0
T3a, N0, M0
T3b, N0, M0
T1-T3, N1, M0
T1-T3, N2, M0
T4, any N, M0
Any T, any N, M1
Grade of endometrial cancer
The grade of endometrial cancer refers to how the cancer cells
look under a microscope. Knowing the grade can help your doctor decide which treatment options are best for you. Endometrial cancer cells are described as
well-differentiated, moderately differentiated, or poorly differentiated.
Differentiation is a term used to describe how clearly the cancer cells can be
distinguished from the surrounding normal tissues and how normal or abnormal
the cells look.
GX. Grade cannot be
G3-G4: Poorly differentiated
American Joint Committee on Cancer (2010). Corpus uteri. In AJCC Cancer Staging Manual, 7th ed., pp. 403-418. New York: Springer.
Primary Medical Reviewer
Sarah Marshall, MD - Family Medicine
Specialist Medical Reviewer
Ross Berkowitz, MD - Obstetrics and Gynecology
November 29, 2010
WebMD Medical Reference from Healthwise
November 29, 2010
This information is not intended to replace the advice of a doctor.
Healthwise disclaims any liability for the decisions you make based on this