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Acupuncture (PDQ®): Complementary and alternative medicine - Health Professional Information [NCI] - Human / Clinical Studies

Table 4. Clinical Studies of Acupuncture: Vasomotor Symptomsa

Reference Citation(s)Type of StudyCondition TreatedNo. of Patients: Enrolled; Treated; ControlbStrongest Benefit ReportedcConcurrent Therapy (Yes/No/ Unknown)dLevel of Evidence Scoree
EA = electroacupuncture; No. = number; RCT = randomized controlled trial; SSRIs = selective serotonin reuptake inhibitors.
a Refer to text and theNCI Dictionary of Cancer Termsfor additional information and definition of terms.
b Number of patients treated plus number of patient controls may not equal number of patients enrolled; number of patients enrolled equals number of patients initially considered by the researcher who conducted a study; number of patients treated equals number of enrolled patients who were given the treatment being studied AND for whom results were reported.
c Strongest evidence reported that the treatment under study has anticancer activity or otherwise improves the well-being of cancer patients.
d Concurrent therapy for symptoms treated (not cancer).
e For information about levels of evidence analysis and an explanation of the level of evidence scores, refer toLevels of Evidence for Human Studies of Cancer Complementary and Alternative Medicine.
fP< .001, versus baseline.
[43]RCTHot flashes in breast cancer patients treated with tamoxifen and aromatase inhibitors72; 42; 30Reduction of hot flashes but no statistical difference between acupuncture and sham treatmentYes (SSRIs)1iiC
[52]RCTHot flushes45; 27 EA; 18 hormone therapyVasomotor symptoms improvedUnknown1iiC
[45]RCTHot flashes50; 25; 25Vasomotor symptoms improvedYes (tamoxifen or arimidex)1iiC
[53]RCTHot flashes in breast cancer patients treated with tamoxifen84; 74; noneDecrease in severity and frequency in hot flushes and sweatingYes (tamoxifen)1iiC
[44]Phase I pilot studyMenopausal symptoms in breast cancer patients treated with tamoxifen15; 15 acupuncture; noneAnxiety, depression, and somatic and vasomotor symptoms improvedfNo3iiiC
[46]Pilot study/case seriesHot flashes in patients with prostate cancer25; 22; none55% treatment for hot flashesNo3iiiC
[9]Nonconsecutive case seriesNight sweats, hot flashes in patients with cancer6; 6 acupuncture; noneSymptoms improvedYes (not specified)3iiiC
[51]Nonconsecutive case seriesVasomotor symptoms for breast and prostate cancer194; 194; none79% showed 50% or greater reduction in hot flashesNo3iiiC
[49]Nonconsecutive case seriesVasomotor symptoms for prostate cancer17; 14; noneDecreased hot flashesYes (androgen ablation therapy)3iiiC
[50]Prospective case seriesHot flashes and night sweats54; 50; noneDecreased hot flashes and night sweats and improved physical and emotional well-beingYes (tamoxifen)3iiiC
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