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    Acupuncture (PDQ®): Complementary and alternative medicine - Health Professional Information [NCI] - Human / Clinical Studies

    Table 4. Clinical Studies of Acupuncture: Vasomotor Symptomsa

    Reference Citation(s) Type of Study Condition Treated No. of Patients: Enrolled; Treated; Controlb Strongest Benefit Reportedc Concurrent Therapy (Yes/No/ Unknown)d Level of Evidence Scoree
    EA = electroacupuncture; No. = number; RCT = randomized controlled trial; SSRIs = selective serotonin reuptake inhibitors.
    a Refer to text and theNCI Dictionary of Cancer Termsfor additional information and definition of terms.
    b Number of patients treated plus number of patient controls may not equal number of patients enrolled; number of patients enrolled equals number of patients initially considered by the researcher who conducted a study; number of patients treated equals number of enrolled patients who were given the treatment being studied AND for whom results were reported.
    c Strongest evidence reported that the treatment under study has anticancer activity or otherwise improves the well-being of cancer patients.
    d Concurrent therapy for symptoms treated (not cancer).
    e For information about levels of evidence analysis and an explanation of the level of evidence scores, refer toLevels of Evidence for Human Studies of Cancer Complementary and Alternative Medicine.
    f P< .001, versus baseline.
    [43] RCT Hot flashes in breast cancer patients treated with tamoxifen and aromatase inhibitors 72; 42; 30 Reduction of hot flashes but no statistical difference between acupuncture and sham treatment Yes (SSRIs) 1iiC
    [52] RCT Hot flushes 45; 27 EA; 18 hormone therapy Vasomotor symptoms improved Unknown 1iiC
    [45] RCT Hot flashes 50; 25; 25 Vasomotor symptoms improved Yes (tamoxifen or arimidex) 1iiC
    [53] RCT Hot flashes in breast cancer patients treated with tamoxifen 84; 74; none Decrease in severity and frequency in hot flushes and sweating Yes (tamoxifen) 1iiC
    [44] Phase I pilot study Menopausal symptoms in breast cancer patients treated with tamoxifen 15; 15 acupuncture; none Anxiety, depression, and somatic and vasomotor symptoms improvedf No 3iiiC
    [46] Pilot study/case series Hot flashes in patients with prostate cancer 25; 22; none 55% treatment for hot flashes No 3iiiC
    [9] Nonconsecutive case series Night sweats, hot flashes in patients with cancer 6; 6 acupuncture; none Symptoms improved Yes (not specified) 3iiiC
    [51] Nonconsecutive case series Vasomotor symptoms for breast and prostate cancer 194; 194; none 79% showed 50% or greater reduction in hot flashes No 3iiiC
    [49] Nonconsecutive case series Vasomotor symptoms for prostate cancer 17; 14; none Decreased hot flashes Yes (androgen ablation therapy) 3iiiC
    [50] Prospective case series Hot flashes and night sweats 54; 50; none Decreased hot flashes and night sweats and improved physical and emotional well-being Yes (tamoxifen) 3iiiC
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