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    Gastrointestinal Carcinoid Tumors Treatment (PDQ®): Treatment - Health Professional Information [NCI] - Stage Information for Gastrointestinal Carcinoid Tumors

    Definitions of TNM

    The American Joint Committee on Cancer (AJCC) has designated staging by TNM classification to define neuroendocrine tumors.[1]

    This staging system is new for the 7th edition of the AJCC Cancer Staging Manual.[1]

    Neuroendocrine Tumors: Stomach

    Table 2. Primary Tumor (T)a

    a Reprinted with permission from AJCC: Neuroendocrine tumors. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 181-9.
    TX Primary tumor cannot be assessed.
    T0 No evidence of primary tumor.
    Tis Carcinoma in situ /dysplasia (tumor size <0.5 mm), confined to mucosa.
    T1 Tumor invades lamina propria or submucosa and ≤1 cm in size.
    T2 Tumor invades muscularis propria or >1 cm in size.
    T3 Tumor penetrates subserosa.
    T4 Tumor invades visceral peritoneum (serosal) or other organs or adjacent structures.
    For any T, add (m) for multiple tumors.

    Table 3. Regional Lymph Nodes (N)a

    a Reprinted with permission from AJCC: Neuroendocrine tumors. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 181-9.
    NX Regional lymph nodes cannot be assessed.
    N0 No regional lymph node metastasis.
    N1 Regional lymph node metastasis.

    Table 4. Distant Metastases (M)a

    a Reprinted with permission from AJCC: Neuroendocrine tumors. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 181-9.
    M0 No distant metastases.
    M1 Distant metastasis.

    Neuroendocrine Tumors: Duodenum/Ampulla/Jejunum/Ileum

    Table 5. Primary Tumor (T)a

    a Reprinted with permission from AJCC: Neuroendocrine tumors. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 181-9.
    b Tumor limited to ampulla of Vater for ampullary gangiocytic paraganglioma.
    TX Primary tumor cannot be assessed.
    T0 No evidence of primary tumor.
    T1 Tumor invades lamina propria or submucosa and size ≤1 cmb(small intestinal tumors); tumor ≤1 cm (ampullary tumors).
    T2 Tumor invades muscularis propria or size >1 cm (small intestinal tumors); tumor >1 cm (ampullary tumors).
    T3 Tumor invades through the muscularis propria into subserosal tissue without penetration of overlying serosa (jejunal or ileal tumors) or invades pancreas or retroperitoneum (ampullary or duodenal tumors) or into nonperitonealized tissues.
    T4 Tumor invades visceral peritoneum (serosa) or invades other organs.
    For any T, add (m) for multiple tumors.
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