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Childhood Acute Lymphoblastic Leukemia Treatment (PDQ®): Treatment - Patient Information [NCI] - Treatment Options for Childhood Acute Lymphoblastic Leukemia

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CNS-directed therapy to treat or prevent the spread of leukemia cells to the brain and spinal cord may include the following:

  • Intrathecal chemotherapy.
  • High-dose systemic chemotherapy.
  • Radiation therapy.
  • A clinical trial of a new intrathecal chemotherapy and high-dose systemic chemotherapy regimen and the use of radiation therapy.

Philadelphia chromosome-positive ALL

Treatment of Philadelphia chromosome-positive childhood ALL may include the following:

  • Combination chemotherapy followed by targeted therapy with a tyrosine kinase inhibitor (imatinib mesylate).
  • Combination chemotherapy followed by stem cell transplant using stem cells from a donor.
  • A clinical trial of combination chemotherapy and a new tyrosine kinase inhibitor, with or without stem cell transplant.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with T-cell childhood acute lymphoblastic leukemia and Philadelphia chromosome positive childhood precursor acute lymphoblastic leukemia. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

Recurrent Childhood Acute Lymphoblastic Leukemia

Standard treatment of recurrent childhood acute lymphoblastic leukemia (ALL) for leukemia that comes back in the bone marrow may include the following:

  • Combination chemotherapy.
  • Chemotherapy with or without total-body irradiation followed by a stem cell transplant, using stem cells from a donor.

Standard treatment of recurrent childhood acute lymphoblastic leukemia (ALL) for leukemia that comes back outside the bone marrow may include the following:

  • Chemotherapy and radiation therapy for cancer that comes back in the testicles only.
  • Combination chemotherapy and intrathecal chemotherapy with radiation therapy to the brain and/or spinal cord for cancer that comes back in the brain and spinal cord only.

Some of the treatments being studied in clinical trials for recurrent childhood ALL include the following:

  • New anticancer drugs and new combination chemotherapy treatments.
  • Combination chemotherapy and new kinds of targeted therapies.

Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with recurrent childhood acute lymphoblastic leukemia. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

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WebMD Public Information from the National Cancer Institute

Last Updated: February 25, 2014
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