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Treatment Options for Childhood Acute Lymphoblastic Leukemia

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    Treatment of infants with ALL may include the following:

    • Combination chemotherapy.
    • Chemotherapy followed by a donor stem cell transplant has been studied but it is not clear if this treatment improves survival.
    • A clinical trial of chemotherapy followed by a donor stem cell transplant for infants with certain gene changes.
    • A clinical trial of combination chemotherapy and targeted therapy with a tyrosine kinase inhibitor.

    CNS-directed therapy to treat or prevent the spread of leukemia cells to the brain and spinal cord may include the following:

    • Intrathecal chemotherapy.
    • High-dose systemic chemotherapy.

    Children and teenagers with ALL

    Treatment of ALL in children and teenagers (10 years and older) may include the following:

    • Combination chemotherapy.
    • A clinical trial of a new combination chemotherapy regimen.
    • A clinical trial of a new anticancer drug, new doses of certain anticancer drugs, and the use of radiation therapy to the brain. The chemotherapy dose and/or schedule depends on the patient's risk group after induction therapy.

    CNS-directed therapy to treat or prevent the spread of leukemia cells to the brain and spinal cord may include the following:

    • Intrathecal chemotherapy.
    • High-dose systemic chemotherapy.
    • Radiation therapy.
    • A clinical trial of a new intrathecal chemotherapy and high-dose systemic chemotherapy regimen and the use of radiation therapy.

    Philadelphia chromosome-positive ALL

    Treatment of Philadelphia chromosome-positive childhood ALL may include the following:

    • Combination chemotherapy followed by targeted therapy with a tyrosine kinase inhibitor (imatinib mesylate).
    • Combination chemotherapy followed by stem cell transplant using stem cells from a donor.
    • A clinical trial of combination chemotherapy and a new tyrosine kinase inhibitor, with or without stem cell transplant.

    Check for U.S. clinical trials from NCI's list of cancer clinical trials that are now accepting patients with T-cell childhood acute lymphoblastic leukemia and Philadelphia chromosome positive childhood precursor acute lymphoblastic leukemia. For more specific results, refine the search by using other search features, such as the location of the trial, the type of treatment, or the name of the drug. General information about clinical trials is available from the NCI Web site.

    Recurrent Childhood Acute Lymphoblastic Leukemia

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