Painless swelling of one or more lymph nodes, without a recent infection.
Symptoms stemming from pressure of swollen lymph nodes on nearby organs or structures. They may include a cough, shortness of breath, abdominal pain or swelling, a Horner's syndrome (a neurological problem affecting the face and eyes, due to damage to nerves in the neck), nerve pain, and leg swelling.
Fever, either persistent or alternating with periods of normal temperatures, for 14 consecutive days or longer. These fevers usually occur twice daily, usually in the late afternoon and early evening, and rarely are greater than 102 degrees Farenheit.
Pain in lymph nodes or abdomen after drinking alcohol.
Drenching night sweats and/or chills lasting for 14 consecutive days or longer.
Unintentional weight loss (more than 10% over six months).
Increased susceptibility to infections.
Total body itching.
The symptoms of fever, chills, night sweats, and weight loss, occur in 30% of people with Hodgkin lymphoma, usually older adults. These symptoms are usually associated with a more advanced, and more aggressive, disease, with a poorer prognosis.
Standard Treatment Options
Recurrence of Ewing sarcoma is most common within 2 years of initial diagnosis (approximately 80%).[1,2] However, late relapses occurring more than 5 years from initial diagnosis are more common in Ewing sarcoma (13%; 95% confidence interval, 9.4–16.5) than in other pediatric solid tumors. The overall prognosis for patients with recurrent Ewing sarcoma is poor; 5-year survival following recurrence is approximately 10% to 15%.[2,4,5]; [Level of evidence: 3iiA]...