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Children's Vaccines Health Center

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Hib (H. influenzae Type B) Vaccine

Despite its name, the bacterium called Haemophilus influenzae type b, or Hib, does not cause the flu. It does, however, cause Hib disease, a serious health threat to children, especially those under age 5. Fortunately, the Hib vaccine, available since 1992, provides safe and effective protection against that threat.

What Is Hib Disease?

Hib disease is an invasive bacterial infection that at one time was the most common cause of bacterial meningitis; invasive means that germs spread to parts of the body that are normally germ-free. Meningitis is an infection of the membrane that covers the brain and spinal cord. Bacterial meningitis is a serious infection that can cause fever, decline in cognitive ability, coma, and death. It kills from 3% to 6% of the children who have it. And even when children survive, many of them are left with serious nerve and brain damage that can range from blindness to paralysis to mental retardation.

In addition to meningitis, Hib can cause pneumonia; epiglottitis, which is an infection in the throat that can cause breathing difficulties; blood infection; bone infection; and joint infection leading to arthritis.

The Hib germ is spread in droplets that come from sneezing or coughing. Before use of the vaccine, there were about 20,000 cases of Hib disease each year in children under age 5 -- 12,000 of which were meningitis -- and about 1,000 deaths per year.

Can the Hib Vaccine Cause Hib Disease?

The Hib bacterium has a coating; the Hib vaccine is made from this coating, which, when bonded with a protein, can cause the body’s defenses to build up immunity to Hib. Since the whole bacterium isn’t used, it cannot cause Hib infection and so cannot cause Hib disease.

Is the Hib Vaccine Safe and Can It Be Given With Other Vaccines?

The vaccine is safe. The most common side effects include soreness, swelling, or redness at the site of the injection. There are no serious side effects, and severe allergic reactions are rare.

It is safe to give the vaccine with other vaccines or in a combination vaccine. The Hib vaccine is generally given as part of a child’s regular vaccination routine.

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