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Cold, Flu, & Cough Health Center

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Swine Flu Vaccine by October, Say Makers

Manufacturers Tell FDA Panel That Vaccine Could Be Ready for 50 Million People by Mid-October
WebMD Health News
Reviewed by Louise Chang, MD

July 23, 2009 -- Vaccine makers told an FDA panel of experts that they're moving ahead with rushed plans to produce a swine flu vaccine and could have doses ready to distribute to the public by mid-October.

Federal officials are planning a massive fall vaccination campaign against H1N1, the virus that causes swine flu and has caused thousands of hospitalizations and more than 170 deaths since the spring.

The government has devoted billions of dollars to private companies as part of an emergency vaccine production program.

Companies and government officials are rushing to test and produce a swine flu vaccine in time for an expected resurgence of the H1N1 virus in the fall. The effort is potentially complicated by the fact that manufacturers must also continue making a separate vaccine against the seasonal flu, which kills an estimated 36,000 people per year in the U.S.

"Time is really not on our side," FDA official Wellington Sun, MD, said.

Company officials told the FDA panel Thursday that they would probably be able to produce enough vaccine to protect 50 million people by mid-October. That's an uncertain estimate, the companies said.

Up to 100 million doses could be produced by that time, but it's unclear whether it will take one dose or two to generate immunity against H1N1 in most patients.

At the same time, companies warned that the process of growing H1N1 viruses for use in a vaccine has shown lower than usual yields, suggesting vaccine production could go more slowly. Some gave a "worst case scenario" that H1N1 vaccine production may not peak until December or later.

Monitoring for Potential Changes in H1N1 Virus

Scientists are also closely watching H1N1 as it circulates through the flu season in the Southern Hemisphere. Flu vaccines are notorious for rapid genetic shifts that can help them evade vaccines. That's a wild card in vaccine development.

Nancy Cox, MD, PhD, director of the influenza division at the CDC, said H1N1 has so far shown reassuring stability.

"We're continuing to monitor very carefully but we haven't actually seen anything we believe is significant" in terms of increasing virulence, Cox told the panel.

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