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Q: When is it too late in the season to get a flu vaccine?

A: The season generally begins in September or October and can run as late as May, but some seasons behave differently. Throughout the season, we recommend that people get their vaccines if they haven't already. You can never be sure, because flu is unpredictable. ... We recommend getting it as early as possible in the season, so you can establish your immune protection as early as possible.