Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Eltrombopag may slow down how quickly your body processes rosuvastatin.
What might happen:
The amount of rosuvastatin in your blood may increase and may cause harmful effects.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Let your doctor know if you have any unexplained muscle pain, tenderness, weakness, or discoloration of your urine. Your doctor may want to change your cholesterol medicine.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Promacta (eltrombopag) US prescribing information. GlaxoSmithKline April, 2014.
2.Allred AJ, Bowen CJ, Park JW, Peng B, Williams DD, Wire MB, Lee E. Eltrombopag increases plasma rosuvastatin exposure in healthy volunteers. Br J Clin Pharmacol 2011 Aug;72(2):321-9.
3.Crestor (rosuvastatin calcium) US prescribing information. AstraZeneca Pharmaceuticals LP July, 2014.