Moderate. These medicines may cause some risk when taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Sevelamer may bind to ciprofloxacin in your digestive tract and prevent your body from absorbing it.
What might happen:
The amount of ciprofloxacin in your blood may decrease and it may not work as well.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know that you are taking these medicines together. Time your medicines so that you take your ciprofloxacin at least one hour before or three hours after your sevelamer. Let your healthcare professional know if your condition does not improve or worsens. Your doctor may need to change your antibiotic.Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Kays MB, Overholser BR, Mueller BA, Moe SM, Sowinski KM. Effects of sevelamer hydrochloride and calcium acetate on the oral bioavailability of ciprofloxacin. Am J Kidney Dis 2003 Dec;42(6):1253-9.
2.Renagel (sevelamer hydrochloride) US prescribing information. Genzyme Corporation June, 2011.