Serious. These medicines may interact and cause very harmful effects. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
When these two medicines are taken together, cyproheptadine may decrease the effect of metyrapone.
What might happen:
You may experience a decrease in your response to metyrapone.
What you should do about this interaction:
Contact your healthcare professionals (e.g. doctor or pharmacist) as soon as possible about taking these two medicines together. They may already be aware of this interaction and may be monitoring you for it. It may be necessary to stop your dose of cyproheptadine before starting metyrapone. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Plank J, Feldman JM. Adrenal function in the carcinoid syndrome: effects of the serotonin antagonist cyproheptadine. Metabolism 1975 Sep; 24(9):1035-46.
2.Plonk J, Feldman J. Modification of adrenal function by the anti-serotonin agent cyproheptadine. J Clin Endocrinol Metab 1976 Feb;42(2):291-5.