Severe. These medicines may interact and cause very harmful effects and are usually not taken together. Contact your healthcare professional (e.g. doctor or pharmacist) for more information.
How the interaction occurs:
Voriconazole may slow down how quickly your liver processes your cholesterol medicine.
What might happen:
The amount of cholesterol medicine in your blood may increase and cause muscle damage.
What you should do about this interaction:
Let your healthcare professionals (e.g. doctor or pharmacist) know right away that you are taking these medicines together. Your doctor may tell you to stop taking your cholesterol medicine while you are taking voriconazole or change your cholesterol medicine. Let your doctor know right away if you have any unexplained muscle pain, tenderness, or weakness (especially with a fever or unusual tiredness).Your healthcare professionals may already be aware of this interaction and may be monitoring you for it. Do not start, stop, or change the dosage of any medicine before checking with them first.
1.Mevacor (lovastatin) US prescribing information. Merck & Co., Inc. February, 2014.
2.Zocor (simvastatin) US prescribing information. Merck & Co., Inc. February, 2014.
3.Vfend (voriconazole) US prescribing information. Pfizer Inc. February, 2015.
4.Lipitor (atorvastatin) US prescribing information. Pfizer Inc. March, 2015.
5.Cool RM, Gulbis AM. Rhabdomyolysis after concomitant ese of simvastatin and voriconazole in an allogeneic stem cell transplant patient. J Pharm Technol May/June 2013;29(3):135-8.
6.Phansalkar S, Desai AA, Bell D, Yoshida E, Doole J, Czochanski M, Middleton B, Bates DW. High-priority drug-drug interactions for use in electronic health records. J Am Med Inform Assoc 2012 Sep-Oct; 19(5):735-43.