Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Epilepsy Health Center

Font Size

FDA OKs First Generic Depakote

Generic Depakote to Treat Seizures, Migraine Headaches, and Bipolar Disorder
WebMD Health News
Reviewed by Louise Chang, MD

July 29, 2008 -- The FDA today approved the first generic version of Depakote (divalproex sodium) delayed-release tablets. Depakote is approved by the FDA to treat seizures, bipolar disorder, and migraine headaches.

"Generic drugs undergo a rigorous scientific review to ensure that they will provide the patient the same amount of high-quality, safe, and effective drug as the name-brand product," Gary J. Buehler, RPh, director of the FDA's Office of Generic Drugs, says in an FDA news release. "This approval provides an additional treatment option for patients who suffer from epilepsy, bipolar disorder, and migraines."

Generic divalproex sodium will have the same safety warnings as Depakote, including a "black box" warning -- the FDA's sternest warning -- that cautions about the risk of liver damage (hepatoxicity) and inflamed pancreas (pancreatitis), including fatal cases of both. The boxed warning also highlights the risk of birth defects, including neural tube defects.

The FDA has approved the following firms to market divalproex sodium delayed-release tablets: Sun Pharmaceutical Industries Ltd. of Mumbai, India, Genpharm Inc. of Ontario, Canada, Nu-Pharm Inc. of Ontario, Canada, Upsher-Smith Laboratories of Maple Grove, Minn., Sandoz Inc. of Broomfield, Colo., Teva Pharmaceuticals USA of North Wales, Pa., Dr. Reddy's Laboratories of Hyderabad, India, and Lupin Limited of Mumbai, India.

Today on WebMD

human head and brain waves
Causes, symptoms, and treatments.
Grand mal seizure
How is each one different?
marijuana plant
CBD, a plant chemical, may cut down seizures.
prescription bottle
Which medication is right for you?
Seizures Driving
Questions for Doctor Epilepsy
Graces Magic Diet
Pills spilling from bottle in front of clock
first aid kit
Caring Child Epilepsy
Making Home Safe
epilepsy monitoring

WebMD Special Sections