It is possible that the main title of the report Leber Hereditary Optic Neuropathy is not the name you expected. Please check the synonyms listing to find the alternate name(s) and disorder subdivision(s) covered by this report.
- Leber's optic atrophy
- Leber's optic neuropathy
Leber hereditary optic neuropathy (LHON) is mainly characterized by bilateral, painless subacute loss of central vision during young adult life. In most cases, symptoms begin with one eye first, followed a few weeks later by visual failure in the other eye. Extremely rarely there may be neurologic abnormalities, such as peripheral neuropathy, postural tremor, nonspecific myopathy, and movement disorders. LHON is caused by mutations in mitochondrial DNA and it is transmitted by maternal inheritance. LHON affects approximately 1:50,000 people. Many carriers never suffer significant visual loss; males are about four to five times more likely than females to be affected.
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United Mitochondrial Disease Foundation
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National Association for Parents of Children with Visual Impairments (NAPVI)
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National Federation of the Blind
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American Foundation for the Blind
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American Council of the Blind
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Guiding Eyes for the Blind, Inc.
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NIH/National Eye Institute
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Blind Children's Center
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International Foundation for Optic Nerve Disease (IFOND)
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MD Support - The Eyes of the Macular Degeneration Community
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Genetic and Rare Diseases (GARD) Information Center
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National Ophthalmic Genotyping and Phenotyping (eyeGENE®)
National Institutes of Health/National Eye Institute
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Bethesda, MD 20892-1860
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It is possible that the title of this topic is not the name you selected. Please check the Synonyms listing to find the alternate name(s) and Disorder Subdivision(s) covered by this report
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Last Updated: 1/15/2013
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