ACE Inhibitors Help All Heart Patients
Even Those With Moderate Risk or Already on Other Medications May Benefit, Study Shows
WebMD News Archive
Analyzing the Benefits of ACE Inhibitors continued...
But when Dagenais and colleagues controlled for these differences, they
concluded this was not the case.
They found patients who had a very low risk of having a heart attack or stroke-- even
those whose risk was as low as 1.7% per year - lowered the risk even further
when they took an ACE inhibitor.
"The use of ACE inhibitors should be considered in all patients with
vascular disease [atherosclerosis] as long as they can tolerate these agents
and the absolute benefits are judged to be valuable," they write.
Two drug researchers who weighed in on the issue in an editorial published
with the study remain unconvinced.
Giuseppe Remuzzi and Piero Ruggenenti, of Italy's Mario Negri Institute for
Pharmacological Research, take issue with the conclusions from the new
analysis. They write that ACE inhibitors appear to offer "no added benefit
to low-risk patients already on aspirin, beta blockers, and statins."
American Heart Association spokesman Richard Stein, MD, tells WebMD that
patients with heart disease should discuss their treatment
options with their doctor, including whether to add an ACE inhibitor to the
drugs they are already taking.
Stein is director of preventive cardiology at New York City's Beth Israel
"The question, 'Do I add an ACE inhibitor to what I am already doing to
reduce my risk?' is a reasonable one, and for many patients the answer will be
'yes,'" Stein says.