Skip to content

    Infertility & Reproduction Health Center

    Font Size
    A
    A
    A

    Breast Cancer Drug Fights a Cause of Infertility?

    Letrozole improves pregnancy rates in women with polycystic ovary syndrome, researcher says

    WebMD News from HealthDay

    By Steven Reinberg

    HealthDay Reporter

    WEDNESDAY, July 9, 2014 (HealthDay News) -- Women with polycystic ovary syndrome have a better chance of getting pregnant if they take a breast cancer drug instead of the currently preferred medication, a new study suggests.

    Polycystic ovary syndrome -- the most common cause of female infertility in the United States -- causes higher than normal levels of the male hormone androgen, infrequent periods and small cysts on the ovaries. It affects 5 to 10 percent of reproductive-age women, according to background information in the study.

    Currently, doctors typically prescribe clomiphene (Clomid) to boost fertility for women with polycystic ovary syndrome. However, this new study suggests the drug letrozole (Femara) results in better ovulation, conception and birth rates.

    "We found a simple and comparatively safe and vastly more effective treatment for [polycystic ovary syndrome]," said lead researcher Dr. Richard Legro, a professor of obstetrics and gynecology at Penn State University's College of Medicine in Hershey, Penn.

    Clomiphine, which works by stimulating ovulation, has been the standard treatment for years, but has a high rate of multiple births, Legro said.

    Letrozole, a treatment for breast cancer in postmenopausal women, works by blocking estrogen production, tricking the ovaries into producing more of the hormone, he explained.

    The new study, funded by the U.S. National Institutes of Health, was published July 10 in the New England Journal of Medicine.

    Researchers found that almost 28 percent of the women taking letrozole had babies after five cycles, compared with about 19 percent of those taking clomiphene.

    Also, women taking letrozole had fewer twin pregnancies, compared with those taking clomiphene -- about 3 percent versus 7 percent, the study found.

    "Clomiphine may be trumped," Legro said. "To see a 40 percent improvement in birth rate is a huge difference."

    Whether letrozole will cause more birth defects than other drugs isn't known, Legro said. "We will need other studies to show that the rates of birth defects are actually low -- lower than we would expect in an infertile population," he said.

    Letrozole, a generic drug, is relatively inexpensive. Thirty pills cost around $56, similar to the cost of clomiphene, Legro said. "This is an affordable form of infertility treatment," he said.

    Today on WebMD

    Four pregnant women standing in a row
    How much do you know about conception?
    Couple with surrogate mother
    Which one is right for you?
     
    couple lying in grass holding hands
    Why Dad's health matters.
    couple viewing positive pregnancy test
    6 ways to improve your chances.
     
    Which Treatment Is Right For You
    Slideshow
    Conception Myths
    Article
     
    eddleman prepare your body pregnancy
    Video
    Conception
    Slideshow
     
    Charting Your Fertility Cycle
    Article
    Fertility Specialist
    Article
     
    Understanding Fertility Symptoms
    Article
    invitro fertilization
    Article
     

    WebMD Special Sections