Skip to content

    Migraines & Headaches Health Center

    Font Size
    A
    A
    A

    New Migraine Drug Promising

    May Help Patients Who Don’t Respond to Triptans

    Study Details continued...

    Participants were told to take the medication one time only, when they developed moderate to severe migraine pain. They were also asked to keep a diary, noting a timeline of how their symptoms and pain were affected after taking their medication. Various doses of the new medication were tried, from 25 milligrams to 600 milligrams. "We found the 300 or 600 milligrams of MK-0974 was effective at stopping the headache at two hours," Ho says.

    Overall, about two-thirds of those who took MK-0974 or who took Maxalt for migraine pain relief reported a reduction in pain at two hours.

    However, nearly 50% of patients taking MK-0974 at the 300-milligram dose reported being pain-free at two hours, compared with only 33% of those who took Maxalt and 14% of those who took a placebo.

    The study also showed that nearly 40% of those who took the new drug were still pain-free at 24 hours, but Ho's team says only about 20% of Maxalt users were.

    Second Opinions

    "I'm enthused," says Seymour Diamond, MD, a headache specialist and founder of the Diamond Headache Clinic in Chicago, when told of the new study findings.

    If approved, the new medication may eventually prove beneficial for patients who don’t respond to the triptans as well as those who can't take them, he says. "Not every [migraine] drug is for everybody."

    • Tried everything to calm your migraines? Get support and feedback from Indie Cooper-Guzman, RN, on our Migraines message board.
    1 | 2

    Today on WebMD

    Business woman with hand on face and eyes closed
    What aura looks like, triggers, and more.
    woman with migraine
    Get the truth about migraines.
     
    headache in the bedroom
    Keep headaches from ruining your sex life.
    woman with hands on head
    Test your knowledge of triggers, types, and more.
     
    woman with migraine
    Quiz
    drinking coffee
    Article
     
    Migraines Headaches Basics
    Article
    acupuncture needles in woman's back
    Slideshow
     
    Tired young man
    Slideshow
    spraying perfume
    Article
     
    man with a headache
    Article
    headache in the bedroom
    Article