Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Migraines & Headaches Health Center

Font Size

Migraine Guidelines Focus on Prevention

Key Medications Listed to Help Prevent Migraine Headaches
WebMD Health News

April 23, 2012 -- New guidelines may help people with frequent migraine headaches get their lives back on track.

The migraine prevention guidelines will be presented at the American Academy of Neurology's annual meeting in New Orleans and published simultaneously in the journal Neurology.

About 36 million people in the U.S. have migraine headaches, according to the Migraine Research Foundation. Migraines are painful, often disabling headaches that may be accompanied by nausea, vomiting, and sensitivity to light.

For some, migraines are few and far between and respond well to available treatments. Others experience more frequent headaches that interfere with their life and don't respond well to treatments. The latter group may be candidates for the preventive treatments outlined in the guidelines. Preventive treatments usually are taken every day to prevent attacks from occurring as often and to lessen their severity and duration when they do occur.

About 38% of people with migraine headaches could benefit from prevention, but less than a third of them use them, says guideline author Stephen D. Silberstein, MD, of Jefferson Headache Center at Thomas Jefferson University in Philadelphia, in a news release. Researchers analyzed studies on migraine prevention treatments to determine which are or are not effective.

New Migraine Guidelines Focus on Headache Prevention

According to the new guidelines, effective migraine preventive treatments include:

  • The anti-seizure drugs Depacon (valproate sodium), Depakote (divalproex sodium), and Topamax (topiramate)
  • The blood pressure medications metoprolol, propranolol, and timolol

The anti-seizure drug Lamictal (lamotrigine) is not effective in preventing migraine, the guidelines state.

Certain nonsteroidal anti-inflammatory drugs (NSAIDS) and complementary therapies can also help prevent migraine headache. These include:

  • Petasites, an herb also known as butterbur
  • NSAIDs including fenoprofen, ibuprofen, ketoprofen, naproxen, and naproxen sodium
  • Histamine shots, which are a common allergy/asthma treatment
  • Magnesium, a mineral
  • MIG-99, an herb also known as feverfew
  • Riboflavin or vitamin B12

There is not enough evidence to suggest a role for aspirin or the NSAID indomethacin as way to stave off migraine headache.

Do You Need Migraine Prevention Treatment?

Mark W. Green, MD, says that anyone who has six or more migraine attacks a month or someone who has fewer migraines that don't respond to treatments is a potential candidate. Green is the director of the Center for Headache and Pain Medicine and professor of neurology and anesthesiology at the Mount Sinai School of Medicine in New York City.

Today on WebMD

Business woman with hand on face and eyes closed
What aura looks like, triggers, and more.
woman with migraine
Get the truth about migraines.
headache in the bedroom
Keep headaches from ruining your sex life.
woman with hands on head
Test your knowledge of triggers, types, and more.
woman with migraine
drinking coffee
Migraines Headaches Basics
acupuncture needles in woman's back
Tired young man
spraying perfume
man with a headache
headache in the bedroom