Find Information About:

Drugs & Supplements

Get information and reviews on prescription drugs, over-the-counter medications, vitamins, and supplements. Search by name or medical condition.

Pill Identifier

Pill Identifier

Having trouble identifying your pills?

Enter the shape, color, or imprint of your prescription or OTC drug. Our pill identification tool will display pictures that you can compare to your pill.

Get Started

My Medicine

Save your medicine, check interactions, sign up for FDA alerts, create family profiles and more.

Get Started

WebMD Health Experts and Community

Talk to health experts and other people like you in WebMD's Communities. It's a safe forum where you can create or participate in support groups and discussions about health topics that interest you.

  • Second Opinion

    Second Opinion

    Read expert perspectives on popular health topics.

  • Community


    Connect with people like you, and get expert guidance on living a healthy life.

Got a health question? Get answers provided by leading organizations, doctors, and experts.

Get Answers

Sign up to receive WebMD's award-winning content delivered to your inbox.

Sign Up

Font Size

Altered Stem Cells Limit Transplant Rejection

Approach Could Free Organ Patients From Anti-Rejection Drugs
WebMD Health News
Reviewed by Laura J. Martin, MD

March 7, 2012 -- New research holds the promise of freeing many organ transplant patients from a lifetime of anti-rejection drugs.

In the first study of its kind, eight kidney transplant patients received stem cells from their kidney donors manipulated to “trick” their bodies into accepting the foreign organ as its own.

Transplant recipients who are not perfectly matched with their donors typically take several drugs a day for the rest of their lives to keep their bodies from rejecting the new organ and to treat the side effects of those drugs.

Lindsay Porter, who was the last of the eight patients enrolled in the new study, had her kidney transplant in the summer of 2010 and was weaned off all anti-rejection drugs within a year.

The Chicago actress and mother says she feels better than she has in 15 years and sometimes has to remind herself that she had a kidney transplant.

“I was 45 when I had the surgery, and I knew I would probably need another kidney at some point,” she tells WebMD. “The opportunity to have a transplant that would last for the rest of my life and to avoid all of those drugs was very appealing.”

Stem Cells Made Transplant Friendly

The ongoing research is the culmination of many years of work by researcher Suzanne Ildstad, MD, of the University of Louisville, and other researchers, including transplant surgeon Joseph Leventhal, MD, PhD, of Chicago’s Northwestern University.

The new wrinkle is that organ donors who are not a perfect genetic match with the patient donate blood as well as a kidney for the procedure.

Bone marrow stem cells collected from the blood were processed in an 18-hour procedure to remove cells associated with organ rejection, leaving behind “facilitating” cells that do not promote rejection, Ildstad says.

Porter and the other patients in the study had chemotherapy about a month before their surgeries to suppress their own immune systems before receiving the manipulated donor stem cells in an effort to increase the likelihood that those stem cells would reprogram the body to accept the transplant.

The procedures were performed in the eight patients between February 2009 and July 2010, and five of the eight have maintained normal kidney function and were able to stop taking all anti-rejection drugs within a year of having their transplants.

Ildstad says the stem cell approach may prove useful for other solid-organ transplants and for many other conditions, including type 1 diabetes and sickle cell anemia.

WebMD Video: Now Playing

Click here to wach video: Dirty Truth About Hand Washing

Which sex is the worst about washing up? Why is it so important? We’ve got the dirty truth on how and when to wash your hands.

Click here to watch video: Dirty Truth About Hand Washing