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What Are Autoimmune Disorders?

Medically Reviewed by Jennifer Robinson, MD on May 05, 2022

Immune system disorders cause abnormally low activity or over activity of the immune system. In cases of immune system overactivity, the body attacks and damages its own tissues (autoimmune diseases). Immune deficiency diseases decrease the body's ability to fight invaders, causing vulnerability to infections.

In response to an unknown trigger, the immune system may begin producing antibodies that instead of fighting infections, attack the body's own tissues. Treatment for autoimmune diseases generally focuses on reducing immune system activity. Examples of autoimmune diseases include:

  • Rheumatoid arthritis. The immune system produces antibodies that attach to the linings of joints. Immune system cells then attack the joints, causing inflammation, swelling, and pain. If untreated, rheumatoid arthritis causes gradually causes permanent joint damage. Treatments for rheumatoid arthritis can include various oral or injectable medications that reduce immune system overactivity. See charts that list rheumatoid arthritis drugs and their side effects.
  • Systemic lupus erythematosus (lupus). People with lupus develop autoimmune antibodies that can attach to tissues throughout the body. The joints, lungs, blood cells, nerves, and kidneys are commonly affected in lupus. Treatment often requires daily oral prednisone, a steroid that reduces immune system function. Read an overview on lupus symptoms and treatments.
  • Inflammatory bowel disease (IBD). The immune system attacks the lining of the intestines, causing episodes of diarrhea, rectal bleeding, urgent bowel movements, abdominal pain, fever, and weight loss. Ulcerative colitis and Crohn's disease are the two major forms of IBD. Oral and injected immune-suppressing medicines can treat IBD. Learn about the differences between ulcerative colitis and Crohn's disease.
  • Multiple sclerosis (MS). The immune system attacks nerve cells, causing symptoms that can include pain, blindness, weakness, poor coordination, and muscle spasms. Various medicines that suppress the immune system can be used to treat multiple sclerosis. Read more on multiple sclerosis drugs and their side effects.
  • Type 1 diabetes mellitus. Immune system antibodies attack and destroy insulin-producing cells in the pancreas. At diagnosis, people with type 1 diabetes require insulin injections to survive. Learn about the symptoms to look for in type 1 diabetes.
  • Guillain-Barre syndrome. The immune system attacks the nerves controlling muscles in the legs and sometimes the arms and upper body. Weakness results, which can sometimes be severe. Filtering the blood with a procedure called plasmapheresis is the main treatment for Guillain-Barre syndrome. 
  • Chronic inflammatory demyelinating polyneuropathy. Similar to Guillain-Barre, the immune system also attacks the nerves in CIDP, but symptoms last much longer. About 30% of patients can become confined to a wheelchair if not diagnosed and treated early. Treatment for CIDP and GBS are essentially the same. Find out what the treatment options are for CIDP.
  • Psoriasis. In psoriasis, immune system blood cells called T-cells collect in the skin. The immune system activity stimulates skin cells to reproduce rapidly, producing silvery, scaly plaques on the skin. See a photo of what psoriasis looks like.
  • Graves' disease. The immune system produces antibodies that stimulate the thyroid gland to release excess amounts of thyroid hormone into the blood (hyperthyroidism). Symptoms of Graves' disease can include bulging eyes as well as weight loss, nervousness, irritability, rapid heart rate, weakness, and brittle hair. Destruction or removal of the thyroid gland, using medicines or surgery, is usually required to treat Graves' disease. Learn more about treatments for Graves' disease.
  • Hashimoto's thyroiditis. Antibodies produced by the immune system attack the thyroid gland, slowly destroying the cells that produce thyroid hormone. Low levels of thyroid hormone develop (hypothyroidism), usually over months to years. Symptoms include fatigue, constipation, weight gain, depression, dry skin, and sensitivity to cold. Taking a daily oral synthetic thyroid hormone pill restores normal body functions. Find out more on treatments for an underactive thyroid.
  • Myasthenia gravis. Antibodies bind to nerves and make them unable to stimulate muscles properly. Weakness that gets worse with activity is the main symptom of myasthenia gravis. Mestinon (pyridostigmine) is the main medicine used to treat myasthenia gravis. Read an overview on the symptoms of myasthenia gravis.
  • Scleroderma.  Also known as systemic sclerosis.  It is an autoimmune chronic connective disease that causes inflammation in the skin and other places in the body.  This inflammation causes the body to make too much collagen, which leads to visible hardening of the skin and damage to your blood vessels and other internal organs, such as the heart, lungs, and kidneys.  It has no cure, while the goals of treatment are to relieve symptoms and stop progression of the disease.”
  • Vasculitis. The immune system attacks and damages blood vessels in this group of autoimmune diseases. Vasculitis can affect any organ, so symptoms vary widely and can occur almost anywhere in the body. Treatment includes reducing immune system activity, usually with prednisone or another corticosteroid. Learn more about vasculitis symptoms and treatments.

Show Sources

SOURCES:
Goldman, L. Cecil Medicine, Saunders, 2007.
Firestein, G. Kelley's Textbook of Rheumatology, W.B. Saunders Company, 2008.

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