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Study Probes Deep Brain Stimulation Failures

Study Shows Procedure Offers Benefits, but Some Complications Preventable
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WebMD Health News

June 13, 2005 - A new report about deep brain stimulation deep brain stimulation failures shows complications from the procedure may be avoidable.

The report in the Archives of Neurology does not dismiss deep brain stimulation, an FDA-approved treatment for Parkinson's disease, Parkinson's disease, essential tremor, and uncontrolled muscle movement (dystonia). In fact, the doctors who wrote the report say "deep brain stimulation offers dramatic benefits for appropriate candidates."

They also caution that the 41 cases they describe don't represent everyone who gets deep brain stimulation. However, the complications experienced by those patients were "potentially preventable," write the University of Florida's Michael Okun, MD, and colleagues.

What Happened

In deep brain stimulation, electrical pulses are delivered by electrodes that are placed inside the brain. The electrodes are connected by wires to a type of pacemaker that is implanted under the skin of the chest.

The 41 patients described in the report came to the University of Florida Movement Disorders Center or Beth Israel Movement Disorders Center citing disappointment with deep brain stimulation. The decision to use deep brain stimulation and the devices' implantation happened elsewhere.

Issues included electrodes that weren't placed in the best spot, dead batteries, and improperly programmed devices.

What's more, five patients didn't have one of the three conditions approved for deep brain stimulation treatment, even though nearly three out of four had been evaluated by a movement-disorders neurologist before the procedure.

More Than Half Improved

Ultimately, about half (51%) of the patients had "good" outcomes, after appropriate interventions. Another 15% improved modestly, while 34% had "persistently poor outcomes despite maximal intervention," says the report.

Some cases involved tweaking the medications that the patients were taking. "Patients with movement disorders, with and without deep brain stimulation, require frequent medical adjustments," say Okun and colleagues.

Report's Recommendations

There has been a surge in the number of centers offering deep brain stimulation since the FDA approved the procedure, according to the report. However, there currently is no standard screening for deep brain stimulation surgery, and even the best screening isn't perfect, says the report.

Ideally, a multispecialty team would coordinate treatment -- monitoring medications and following up with the surgeon, say Okun and colleagues. They note that implanting centers are becoming more experienced.

"We are hopeful that this experience, along with ongoing efforts to educate deep brain stimulation practitioners regarding effective practices, will result in global improvement in the outcomes of deep brain stimulation surgery," they write.

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