Skip to content
Font Size

Hormone Therapy for Prostate Cancer (Androgen Deprivation Therapy, or ADT) - Topic Overview

continued...

Sometimes androgen deprivation (orchiectomy or an LH-RH agonist) and an antiandrogen are used together for treatment. This targets the testosterone made by the testicles and the adrenal glands. It is called a combined androgen blockade (CAB). According to research studies, men who had CAB that included flutamide or nilutamide lived longer than the men who had only androgen deprivation therapy.3

Other hormone therapies may include the use of medicines such as megestrol, estrogen, aminoglutethimide combined with hydrocortisone, and corticosteroids (prednisone, dexamethasone, and hydrocortisone).

Timing of hormone therapy

Research does not clearly show whether starting hormone therapy before symptoms appear allows men to live longer than if they waited until after symptoms appear to start taking medicine.3 Men who start hormone therapy almost always stay on it for the rest of their lives. So waiting until symptoms appear may allow men to delay the serious side effects of hormone therapy.

Alternatives to conventional hormone therapy

  • Intermittent androgen deprivation (IAD). This involves cycles of hormone therapy medicines. Taking breaks during hormone therapy gives men the chance to recover their ability to function sexually. It also gives relief from the other side effects of hormone therapy, including hot flashes and the effects on energy as well as bone and muscle mass. The long-term survival outcome of IAD compared to conventional ADT is not yet known.
  • Antiandrogen monotherapy. Antiandrogens are medicines that block the action of androgens in the body. Antiandrogen monotherapy means taking antiandrogens without other hormone medicines.
1|2|3
Next Article:

Hormone Therapy for Prostate Cancer (Androgen Deprivation Therapy, or ADT) Topics

Today on WebMD

man with doctor
Symptoms, risks, treatments
man coughing
Men shouldn’t ignore
 
prostate cancer cells
What does this diagnosis mean?
doctor and male patient
Is it worth it?
 
cancer fighting foods
SLIDESHOW
15 Cancer Symptoms Men Ignore
FEATURE
 
Prostate Enlarged
VIDEO
Picture Of The Prostate
ANATOMY
 
Prostate Cancer Quiz
QUIZ
screening tests for men
SLIDESHOW
 
Prostate Cancer Symptoms
VIDEO
Vitamin D
SLIDESHOW