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Stage Information for Prostate Cancer

    Table 5. Pathologic (pT)a,b

    p = Pathologic; T = Primary tumor.
    Reprinted with permission fromAJCC: Prostate. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 457-68.
    a There is no pathologic T1 classification.
    b Positive surgical margin should be indicated by an R1 descriptor (residual microscopic disease).
    pT2Organ confined.
    pT2aUnilateral, ≤½ of one side.
    pT2bUnilateral, involving >½ of side but not both sides.
    pT2cBilateral disease.
    pT3Extraprostatic extension.
    pT3aExtraprostatic extension or microscopic invasion of bladder neck.b
    pT3bSeminal vesicle invasion.
    pT4Invasion of rectum, levator muscles, and/or pelvic wall.

    Table 6. Anatomic Stage/Prognostic Groupsa

    GroupTNMPSA ng/mlGleason
    T = Primary tumor; N = Regional lymph nodes; M = Distant metastasis; PSA = Prostate-specific antigen.
    Reprinted with permission fromAJCC: Prostate. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 457-68.
    a When either PSA or Gleason is not available, grouping should be determined by T stage and/or either PSA or Gleason as available.
    IT1a–cN0M0PSA <10Gleason ≤6
    T2aN0M0PSA <10Gleason ≤6
    T1–2aN0M0PSA XGleason X
    IIAT1a–cN0M0PSA <20Gleason 7
    T1a–cN0M0PSA ≥10 <20Gleason ≤6
    T2aN0M0PSA <20Gleason ≤7
    T2bN0M0PSA <20Gleason ≤7
    T2bN0M0PSA XGleason X
    IIBT2cN0M0Any PSAAny Gleason
    T1–2N0M0PSA ≥20Any Gleason
    T1–2N0M0Any PSAGleason ≥8
    IIIT3a–bN0M0Any PSAAny Gleason
    IVT4N0M0Any PSAAny Gleason
    Any TN1M0Any PSAAny Gleason
    Any TAny NM1Any PSAAny Gleason

    Table 7. Prognostic Factors (Site-Specific Factors)

    Reprinted with permission fromAJCC: Prostate. In: Edge SB, Byrd DR, Compton CC, et al., eds.: AJCC Cancer Staging Manual. 7th ed. New York, NY: Springer, 2010, pp 457-68.
    Required for stagingPSA.
    Gleason score.
    Clinically significantGleason primary and secondary patterns.
    Gleason tertiary pattern.
    Clinical staging procedures performed.
    Number of biopsy cores examined.
    Number of biopsy cores positive for cancer.
    1|2|3|4|5|6|7

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