Skip to content

    Sexual Conditions Health Center

    Font Size
    A
    A
    A

    Heart Drug for Female Sexual Disorder?

    Candoxatril May Help Treat Sexual Arousal Disorder in Women

    WebMD Health News
    Reviewed by Louise Chang, MD

    July 24, 2006 -- Like Viagra before it, a drug once studied to treat heart problems may help treat sexual dysfunction. But this time it's being tested exclusively for women.

    A new study shows that a modified version of the experimental heart drug Candoxatril was effective at increasing blood flow to the vagina in animal tests.

    If further research confirms these results in humans, the drug may be used to treat female sexual arousal disorder (FSAD).

    Researchers say an estimated 40% of women suffer from FSAD or other forms of sexual dysfuction, such as low libido or pain during intercourse.

    Candoxatril went into clinical trials in the 1990s as a heart failureheart failuremedication but has since become the focus of efforts to develop a medication to treat female sexual arousal disorder.

    How the Drug Works

    Candoxatril is one of several compounds that targets levels of vasoactive intestinal peptide (VIP), which controls blood flow to the vagina. Researchers say decreased blood flow to the vagina is thought to be a key factor in female sexual arousal disorder.

    An enzyme called NEP degrades VIP in the body, and Candoxatril works by blocking NEP.

    In a new study, published in the Journal of Medicinal Chemistry, researchers altered the molecular structure of Candoxatril in order to focus the drug to treat female sexual arousal dysfunction.

    In animal tests, researchers at Pfizer Global Research and Development in the U.K., found the new compound effectively blocked NEP, took effect quickly, and the effect lasted for a relatively short time.

    They say the results suggest that the drug might have similar effects in humans, but further research is needed.

    Today on WebMD

    couple kissing
    See pictures and get the facts.
    husband taking prescription painkillers
    13 things that can kill your sex drive.
     
    close up of cold sore
    How to stop them from spreading.
    Condom Quiz
    What are the symptoms?
     

    HIV Myth Facts
    Slideshow
    STD Overview
    Slideshow
     
    Man tearing a condom packet
    Quiz
    things your guy wish you knew slideshow
    Slideshow
     

    Thoughtful man sitting on bed
    Quiz
    Girls Puberty 10
    Quiz
     
    Couple in bed
    Article
    Young couple holding hands
    Quiz