Citicoline is a natural chemical in the body. It seems to play a role in brain health. It's available as a supplement in the U.S. In other parts of the world, citicoline is sold as a drug. It's used to try and help sharpen thinking in people with blood flow problems in the brain.
D-mannose is used to treat a rare disease called carbohydrate-deficient glycoprotein syndrome type 1b.
This disease is passed down through families. It makes you lose protein through the intestines. Some reports say D-mannose slows down this protein loss and makes your liver work better. It may also reduce bleeding disorders and low blood sugar in people with this disease.
D-mannose may also treat or prevent urinary tract infections (UTIs). Animal research suggests the supplementstops certain bacteria from sticking to the bladder walls.
Scientists think that the bacteria stick to the sugar instead. This helps the bacteria leave the body through your urine. Fewer bacteria in the bladder lowers your risk of a UTI. However, no studies of D-mannose have been done in people to determine if it effectively treats or prevent UTIs.
Some studies suggest D-mannose may play a useful role as a "prebiotic." Prebiotics are substances that may help your body by stimulating the growth of "good" bacteria in your digestive system.
In some lab studies and studies in mice, D-mannose components were shown to increase the growth of "good" bacteria. This suggests D-mannose may have some use for people with dysbiosis, an imbalance in good and bad bacteria.
Always tell your doctor about any supplements you are taking, including natural ones and those bought without a prescription. That way, your doctor can check on any potential side effects or interactions with any medications.